Literature DB >> 20820878

Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts.

Shinichi Saito1, Yoshiharu Takayama, Koko Mizumachi, Chise Suzuki.   

Abstract

Bovine lactoferrin (BLF) enhanced production of hyaluronan in normal human dermal fibroblasts. The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. The promoting effect of BLF was not observed for HAS1. In addition, COL1A1 transcription and collagen synthesis were enhanced by BLF. These observations suggest that BLF promotes wound healing by increasing hyaluronan and type-I collagen synthesis.

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Year:  2010        PMID： 20820878     DOI： 10.1007/s10529-010-0389-3

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  5 in total

1.  Chain gangs: new aspects of hyaluronan metabolism.

Authors:  Michael Erickson; Robert Stern
Journal:  Biochem Res Int       Date:  2011-12-18

2.  Oral Bovine Milk Lactoferrin Administration Suppressed Myopia Development through Matrix Metalloproteinase 2 in a Mouse Model.

Authors:  Shin-Ichi Ikeda; Toshihide Kurihara; Masataro Toda; Xiaoyan Jiang; Hidemasa Torii; Kazuo Tsubota
Journal:  Nutrients       Date:  2020-12-05       Impact factor: 5.717

3.  Discovery of Lactoferrin as a Stimulant for hADSC-Derived EV Secretion and Proof of Enhancement of Resulting EVs through Skin Model.

Authors:  Junho Kim; Ga Eun You; Minkyu Woo; Nicole Hyesoo Chang; Jungsun Lee
Journal:  Int J Mol Sci       Date:  2021-10-12       Impact factor: 5.923

4.  Designing topical hyaluronic acid technology-Size does matter….

Authors:  Alan D Widgerow; Mary E Ziegler; John A Garruto; Deanne Mraz Robinson; Melanie D Palm; Janelle H Vega; Michaela Bell
Journal:  J Cosmet Dermatol       Date:  2022-05-16       Impact factor: 2.189

Review 5.  Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action.

Authors:  Antimo Cutone; Luigi Rosa; Giusi Ianiro; Maria Stefania Lepanto; Maria Carmela Bonaccorsi di Patti; Piera Valenti; Giovanni Musci
Journal:  Biomolecules       Date:  2020-03-15
  5 in total

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