Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation.

Literature DB >> 20820745

Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation.

Barbara Pili¹, L Harivardhan Reddy, Claudie Bourgaux, Sinda Lepêtre-Mouelhi, Didier Desmaële, Patrick Couvreur.

Abstract

A new prodrug of gemcitabine, based on the covalent coupling of squalene to gemcitabine (GemSQ), has been designed to enhance the anticancer activity of gemcitabine, a nucleoside analogue active against a wide variety of tumors. In the present study, the feasibility of encapsulating GemSQ into liposomes either PEGylated or non-PEGylated has been investigated. The in vivo anticancer activity of these formulations has been tested on subcutaneous grafted L1210wt leukemia model and compared to that of free gemcitabine. The liposomal GemSQ appears to be a potential delivery system for the effective treatment of tumors.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2010 PMID： 20820745 DOI： 10.1039/c0nr00132e

Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790

Keyword Cloud
Cited

12 in total

Review 1. Lipid-Drug Conjugate for Enhancing Drug Delivery.

Authors: Danielle Irby; Chengan Du; Feng Li
Journal: Mol Pharm Date: 2017-01-24 Impact factor: 4.939

2. Stereocomplex Prodrugs of Oligo(lactic acid) _n-Gemcitabine in Poly(ethylene glycol)- block-poly(d,l-lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy.

Authors: Yu Tong Tam; Chengbin Huang; Michael Poellmann; Glen S Kwon
Journal: ACS Nano Date: 2018-07-06 Impact factor: 15.881

3. Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor Bearing Mice.

Authors: Krishna Kattel; Goutam Mondal; Feng Lin; Virender Kumar; Ram I Mahato
Journal: Mol Pharm Date: 2016-11-07 Impact factor: 4.939

4. Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.

Authors: Melek Karaca; Rinku Dutta; Yildiz Ozsoy; Ram I Mahato
Journal: Mol Pharm Date: 2016-04-27 Impact factor: 4.939

5. Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification.

Authors: Alexander A Mikhalin; Nikolai M Evdokimov; Liliya V Frolova; Igor V Magedov; Alexander Kornienko; Robert Johnston; Snezna Rogelj; Michaelann S Tartis
Journal: J Liposome Res Date: 2014-12-23 Impact factor: 3.648

Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation.

Review 1. Lipid-Drug Conjugate for Enhancing Drug Delivery.

2. Stereocomplex Prodrugs of Oligo(lactic acid) _n-Gemcitabine in Poly(ethylene glycol)- block-poly(d,l-lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy.

3. Biodistribution of Self-Assembling Polymer-Gemcitabine Conjugate after Systemic Administration into Orthotopic Pancreatic Tumor Bearing Mice.

4. Micelle Mixtures for Coadministration of Gemcitabine and GDC-0449 To Treat Pancreatic Cancer.

5. Lipophilic prodrug conjugates allow facile and rapid synthesis of high-loading capacity liposomes without the need for post-assembly purification.

6. Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells.

7. Development and Characterization of Solid Lipid Nanoparticles Loaded with a Highly Active Doxorubicin Derivative.

Review 8. Evaluation of Polymer Nanoformulations in Hepatoma Therapy by Established Rodent Models.

Review 9. Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives.

10. Enhanced tumor delivery of gemcitabine via PEG-DSPE/TPGS mixed micelles.