| Literature DB >> 20819721 |
Su Jin Jang1, Joo Hyun Kang, Kwang Il Kim, Tae Sup Lee, Yong Jin Lee, Kyo Chul Lee, Kwang Sun Woo, Wee Sup Chung, Hee Chung Kwon, Chun Jeih Ryu, Tae Hyun Choi, Chang Woon Choi, Sang Moo Lim, Gi Jeong Cheon.
Abstract
Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [(125)I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [(18)F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement. 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20819721 DOI： 10.1016/j.canlet.2010.04.028
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679