Literature DB >> 20819441

Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.

Y Zhang1, X Tong.   

Abstract

This study was designed to investigate the expression of four actin-binding proteins, alpha-actinin-4, cofilin 1, fascin and elongation factor 1-alpha 2 (eEF1A2), in samples of breast cancer from 112 patients with different stages of breast cancer (stages T0 - T1, T2 and T3) compared with normal control tissues (n = 33). Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases. Significant up-regulation of cofilin 1 mRNA was associated with stages T0 - T1 and T2; up-regulation seen at stage T3 was not significant compared with control tissue. Fascin mRNA levels were significantly reduced at all three tumour stages (T0 - T1, T2 and T3) compared with control tissue. In conclusion, some components of the actin cytoskeletal system might hold significant potential as targets in future cancer therapies.

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Year:  2010        PMID： 20819441     DOI： 10.1177/147323001003800331

Source DB:  PubMed          Journal:  J Int Med Res        ISSN： 0300-0605            Impact factor:   1.671


  11 in total

1.  Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins.

Authors:  Kalliopi I Pappa; Vasiliki Lygirou; Georgia Kontostathi; Jerome Zoidakis; Manousos Makridakis; Konstantinos Vougas; George Daskalakis; Alexander Polyzos; Nicholas P Anagnou
Journal:  Cancer Genomics Proteomics       Date:  2017 Jul-Aug       Impact factor: 4.069

2.  LMNA knock-down affects differentiation and progression of human neuroblastoma cells.

Authors:  Giovanna Maresca; Manuela Natoli; Marta Nardella; Ivan Arisi; Daniela Trisciuoglio; Marianna Desideri; Rossella Brandi; Simona D'Aguanno; Maria Rita Nicotra; Mara D'Onofrio; Andrea Urbani; Pier Giorgio Natali; Donatella Del Bufalo; Armando Felsani; Igea D'Agnano
Journal:  PLoS One       Date:  2012-09-26       Impact factor: 3.240

3.  Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise.

Authors:  Catarina Correia; Yoan Diekmann; Astrid M Vicente; José B Pereira-Leal
Journal:  Int J Mol Sci       Date:  2014-09-29       Impact factor: 5.923

Review 4.  Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells.

Authors:  Sergey Shishkin; Lidia Eremina; Natalya Pashintseva; Leonid Kovalev; Marina Kovaleva
Journal:  Int J Mol Sci       Date:  2016-12-22       Impact factor: 5.923

5.  Overexpression of cofilin correlates with poor survival in breast cancer: A tissue microarray analysis.

Authors:  Yusufu Maimaiti; Jie Tan; Zeming Liu; Yawen Guo; Yu Yan; Xiu Nie; Bangxing Huang; Jing Zhou; Tao Huang
Journal:  Oncol Lett       Date:  2017-06-19       Impact factor: 2.967

6.  Differential Expression Pattern of Epithelial Mesenchymal Transition Gens: AXL, GAS6, Claudin-1, and Cofilin-1, in Different Stages of Epithelial Ovarian Cancer.

Authors:  Elham Hassani; Mahmood Shekari Khaniani; Mojtaba Saffari; Amirnader Emami Razavi; Reza Shirkoohi; Sima Mansoori Derakhshan
Journal:  Iran J Public Health       Date:  2019-09       Impact factor: 1.429

7.  Study of cofilin 1 gene expression in colorectal cancer.

Authors:  Samira Mousavi; Reza Safaralizadeh; Mohammadali Hosseinpour-Feizi; Arash Azimzadeh-Isfanjani; Shahryar Hashemzadeh
Journal:  J Gastrointest Oncol       Date:  2018-10

Review 8.  Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis.

Authors:  Vanessa Y Tan; Sarah J Lewis; Josephine C Adams; Richard M Martin
Journal:  BMC Med       Date:  2013-02-26       Impact factor: 8.775

9.  Proteomic approaches identify members of cofilin pathway involved in oral tumorigenesis.

Authors:  Giovana M Polachini; Lays M Sobral; Ana M C Mercante; Adriana F Paes-Leme; Flávia C A Xavier; Tiago Henrique; Douglas M Guimarães; Alessandra Vidotto; Erica E Fukuyama; José F Góis-Filho; Patricia M Cury; Otávio A Curioni; Pedro Michaluart; Adriana M A Silva; Victor Wünsch-Filho; Fabio D Nunes; Andréia M Leopoldino; Eloiza H Tajara
Journal:  PLoS One       Date:  2012-12-05       Impact factor: 3.240

10.  Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.

Authors:  Lingxiang Wang; Li Xiong; Zhengchun Wu; Xiongying Miao; Ziru Liu; Daiqiang Li; Qiong Zou; Zhulin Yang
Journal:  World J Surg Oncol       Date:  2018-01-18       Impact factor: 2.754
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