| Literature DB >> 20819413 |
H Qin1, B Liu, T Shi, Y Liu, Y Sun, Y Ma.
Abstract
The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. To summarize the quantitative association between polymorphisms of the tumour necrosis factor-alpha (TNFA) gene and HCC, a meta-analysis of relevant studies was performed. Ten case-control studies involving 1421 HCC cases were identified from the Medline, Embase and Current Contents databases. Combined results based on all studies showed that patients with HCC had a significantly lower frequency of the TNFA gene polymorphism -308GG than healthy controls. When stratifying for race, results were similar among Asians and Caucasians. When comparing with hepatitis B virus infection cases, no statistical association was found. This meta-analysis suggests that TNFA -308GG gene polymorphism is associated with a modest decrease in the risk of HCC.Entities:
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Year: 2010 PMID： 20819413 DOI： 10.1177/147323001003800304
Source DB: PubMed Journal: J Int Med Res ISSN： 0300-0605 Impact factor: 1.671