Literature DB >> 2081719

The loss of antibiotic activity of ciprofloxacin by photodegradation.

G Phillips1, B E Johnson, J Ferguson.   

Abstract

Solutions of ciprofloxacin were irradiated with different wavebands of ultraviolet and visible radiation and the antibiotic activity of the drug was determined against Escherichia coli. A wavelength dependent loss of antibiotic activity was found with maximal effect around 320 nm; no effect occurred with visible irradiation. The degree of the decrease in activity with longer wavelength ultraviolet (UVA) radiation was sufficient to indicate that human exposure to sunlight through window glass (greater than 320 nm) or UVA from tanning sunbeds may result in a significant reduction in both cutaneous and circulating levels of ciprofloxacin.

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Year:  1990        PMID： 2081719     DOI： 10.1093/jac/26.6.783

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  6 in total

1.  Evaluation of physical and chemical changes in pharmaceuticals flown on space missions.

Authors:  Brian Du; Vernie R Daniels; Zalman Vaksman; Jason L Boyd; Camille Crady; Lakshmi Putcha
Journal:  AAPS J       Date:  2011-04-09       Impact factor: 4.009

2.  Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry.

Authors:  M Engler; G Rüsing; F Sörgel; U Holzgrabe
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

Review 3.  Photosensitivity associated with antibacterial agents.

Authors:  N J Wainwright; P Collins; J Ferguson
Journal:  Drug Saf       Date:  1993-12       Impact factor: 5.606

4.  Photostability and biological activity of fluoroquinolones substituted at the 8 position after UV irradiation.

Authors:  M Matsumoto; K Kojima; H Nagano; S Matsubara; T Yokota
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

5.  Reduced phototoxicity of a fluoroquinolone antibacterial agent with a methoxy group at the 8 position in mice irradiated with long-wavelength UV light.

Authors:  K Marutani; M Matsumoto; Y Otabe; M Nagamuta; K Tanaka; A Miyoshi; T Hasegawa; H Nagano; S Matsubara; R Kamide
Journal:  Antimicrob Agents Chemother       Date:  1993-10       Impact factor: 5.191

6.  Photodegradation assessment of ciprofloxacin, moxifloxacin, norfloxacin and ofloxacin in the presence of excipients from tablets by UPLC-MS/MS and DSC.

Authors:  Urszula Hubicka; Paweł Zmudzki; Przemysław Talik; Barbara Zuromska-Witek; Jan Krzek
Journal:  Chem Cent J       Date:  2013-07-31       Impact factor: 4.215
  6 in total

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