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Literature DB >> 20817119

Interleukin-21: a multifunctional regulator of immunity to infections.

John S Yi¹, Maureen A Cox, Allan J Zajac.

Abstract

Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2010 PMID： 20817119 PMCID： PMC2998550 DOI： 10.1016/j.micinf.2010.08.008

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

67 in total

1. IL-21 induces the apoptosis of resting and activated primary B cells.

Authors: Devangi S Mehta; Andrea L Wurster; Matthew J Whitters; Deborah A Young; Mary Collins; Michael J Grusby
Journal: J Immunol Date: 2003-04-15 Impact factor: 5.422

2. IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

Authors: Mari Strengell; Sampsa Matikainen; Jukka Sirén; Anne Lehtonen; Don Foster; Ilkka Julkunen; Timo Sareneva
Journal: J Immunol Date: 2003-06-01 Impact factor: 5.422

3. IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors.

Authors: Simona Sivori; Claudia Cantoni; Silvia Parolini; Emanuela Marcenaro; Romana Conte; Lorenzo Moretta; Alessandro Moretta
Journal: Eur J Immunol Date: 2003-12 Impact factor: 5.532

4. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6.

Authors: Katsutoshi Ozaki; Rosanne Spolski; Rachel Ettinger; Hyoung-Pyo Kim; Gang Wang; Chen-Feng Qi; Patrick Hwu; Daniel J Shaffer; Shreeram Akilesh; Derry C Roopenian; Herbert C Morse; Peter E Lipsky; Warren J Leonard
Journal: J Immunol Date: 2004-11-01 Impact factor: 5.422

5. Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo.

Authors: Katja Brandt; Silvia Bulfone-Paus; André Jenckel; Donald C Foster; Ralf Paus; René Rückert
Journal: J Invest Dermatol Date: 2003-12 Impact factor: 8.551

6. IL-21 induces the functional maturation of murine NK cells.

Authors: Jason Brady; Yoshihiro Hayakawa; Mark J Smyth; Stephen L Nutt
Journal: J Immunol Date: 2004-02-15 Impact factor: 5.422

7. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.

Authors: Haoli Jin; Roberto Carrio; Aixin Yu; Thomas R Malek
Journal: J Immunol Date: 2004-07-01 Impact factor: 5.422

Review 8. Biology of IL-21 and the IL-21 receptor.

Authors: Devangi S Mehta; Andrea L Wurster; Michael J Grusby
Journal: Immunol Rev Date: 2004-12 Impact factor: 12.988

9. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

Authors: Rong Zeng; Rosanne Spolski; Steven E Finkelstein; SangKon Oh; Panu E Kovanen; Christian S Hinrichs; Cynthia A Pise-Masison; Michael F Radonovich; John N Brady; Nicholas P Restifo; Jay A Berzofsky; Warren J Leonard
Journal: J Exp Med Date: 2005-01-03 Impact factor: 14.307

10. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer.

Authors: Mark J Smyth; Morgan E Wallace; Stephen L Nutt; Hideo Yagita; Dale I Godfrey; Yoshihiro Hayakawa
Journal: J Exp Med Date: 2005-06-20 Impact factor: 14.307

35 in total

1. Promotion of a functional B cell germinal center response after Leishmania species co-infection is associated with lesion resolution.

Authors: Katherine N Gibson-Corley; Paola M Boggiatto; Marie M Bockenstedt; Christine A Petersen; Thomas J Waldschmidt; Douglas E Jones
Journal: Am J Pathol Date: 2012-03-17 Impact factor: 4.307

2. Interleukin-21 Induces Short-Lived Effector CD8⁺ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice.

Authors: Naoto Noguchi; Risa Nakamura; Shinya Hatano; Hisakata Yamada; Xun Sun; Naoya Ohara; Yasunobu Yoshikai
Journal: Infect Immun Date: 2018-07-23 Impact factor: 3.441

3. B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection.

Authors: Ichiro Misumi; Jason K Whitmire
Journal: J Immunol Date: 2014-01-22 Impact factor: 5.422

Review 4. T cell exhaustion during persistent viral infections.

Authors: Shannon M Kahan; E John Wherry; Allan J Zajac
Journal: Virology Date: 2015-01-22 Impact factor: 3.616

Review 5. HIV controllers: a multifactorial phenotype of spontaneous viral suppression.

Authors: Jacques Thèze; Lisa A Chakrabarti; Benoît Vingert; Filippos Porichis; Daniel E Kaufmann
Journal: Clin Immunol Date: 2011-08-04 Impact factor: 3.969

6. Complex and Multilayered Role of IL-21 Signaling during Thymic Development.

Authors: Magali M Moretto; SuJin Hwang; Keer Chen; Imtiaz A Khan
Journal: J Immunol Date: 2019-07-24 Impact factor: 5.422

7. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques.

Authors: Luca Micci; Barbara Cervasi; Zachary S Ende; Robin I Iriele; Elane Reyes-Aviles; Carol Vinton; James Else; Guido Silvestri; Aftab A Ansari; Francois Villinger; Savita Pahwa; Jacob D Estes; Jason M Brenchley; Mirko Paiardini
Journal: Blood Date: 2012-09-18 Impact factor: 22.113