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Literature DB >> 20817042

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

Sei Higuchi¹, Makiko Ohji, Maiko Araki, Riyo Furuta, Mai Katsuki, Ryuji Yamaguchi, Yoshiharu Akitake, Kiyoshi Matsuyama, Keiichi Irie, Kenji Mishima, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara.

Abstract

The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.

Entities: Chemical Disease Gene

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Year: 2010 PMID： 20817042 DOI： 10.1016/j.bbr.2010.08.042

Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332

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Cited

11 in total

1. Endocannabinoids: an appetite for fat.

Authors: Vincenzo Di Marzo
Journal: Proc Natl Acad Sci U S A Date: 2011-07-21 Impact factor: 11.205

Review 2. Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

Authors: Jessica R Barson; Irene Morganstern; Sarah F Leibowitz
Journal: ILAR J Date: 2012

3. Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.

Authors: M Carmen Blanco-Gandía; Auxiliadora Aracil-Fernández; Sandra Montagud-Romero; Maria A Aguilar; Jorge Manzanares; José Miñarro; Marta Rodríguez-Arias
Journal: Psychopharmacology (Berl) Date: 2017-04-29 Impact factor: 4.530

Review 4. The Endocannabinoid System and Eating Behaviours: a Review of the Current State of the Evidence.

Authors: Nathaly Aguilera Vasquez; Daiva E Nielsen
Journal: Curr Nutr Rep Date: 2022-08-18

5. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects.

Authors: Tiziana Bisogno; Anu Mahadevan; Roberto Coccurello; Jae Won Chang; Marco Allarà; Yugang Chen; Giacomo Giacovazzo; Aron Lichtman; Benjamin Cravatt; Anna Moles; Vincenzo Di Marzo
Journal: Br J Pharmacol Date: 2013-06 Impact factor: 8.739

6. Hypothalamic QRFP: regulation of food intake and fat selection.

Authors: S D Primeaux; M J Barnes; H D Braymer
Journal: Horm Metab Res Date: 2013-08-26 Impact factor: 2.936

7. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.

Authors: Sei Higuchi; Keiichi Irie; Ryuji Yamaguchi; Mai Katsuki; Maiko Araki; Makiko Ohji; Kazuhide Hayakawa; Shohei Mishima; Yoshiharu Akitake; Kiyoshi Matsuyama; Kenji Mishima; Kenichi Mishima; Katsunori Iwasaki; Michihiro Fujiwara
Journal: PLoS One Date: 2012-06-21 Impact factor: 3.240

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

1. Endocannabinoids: an appetite for fat.

Review 2. Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

3. Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.

Review 4. The Endocannabinoid System and Eating Behaviours: a Review of the Current State of the Evidence.

5. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects.

6. Hypothalamic QRFP: regulation of food intake and fat selection.

7. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.

Review 8. Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity.

Review 9. Hedonic Eating and the "Delicious Circle": From Lipid-Derived Mediators to Brain Dopamine and Back.

10. Cannabinoid CB₁ Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice.

Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

1. Endocannabinoids: an appetite for fat.

Review 2. Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

3. Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.

Review 4. The Endocannabinoid System and Eating Behaviours: a Review of the Current State of the Evidence.

5. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects.

6. Hypothalamic QRFP: regulation of food intake and fat selection.

7. Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences.

Review 8. Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity.

Review 9. Hedonic Eating and the "Delicious Circle": From Lipid-Derived Mediators to Brain Dopamine and Back.

10. Cannabinoid CB1 Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice.

10. Cannabinoid CB₁ Receptors in the Intestinal Epithelium Are Required for Acute Western-Diet Preferences in Mice.