OBJECTIVES: We determined the independent predictive value of serum apolipoprotein (apo) B/LDL-cholesterol ratio for the risk of diabetes, metabolic syndrome (MetS) and coronary heart disease (CHD). DESIGN AND METHODS: Prediction of incident cases was assessed in 2466 adults at 7 years' follow-up. RESULTS: ApoB/LDL ratio was independently associated log-linearly with waist circumference, and, only in men, with HDL-cholesterol in a multivariable regression model. Positive partial correlations existed with fasting insulin, fibrinogen and apo A-I and, only in women, with CRP. Cox regression analyses revealed the two highest apoB/LDL quartiles to be significant determinants of diabetes, at 2-fold RRs, independently of waist circumference, fasting glucose and other confounders. However, apoB/LDL quartiles were not independently associated with CHD in either gender. Only the highest apoB/LDL quartile was associated (RR 1.46) with the development of MetS. Serum apoB/LDL-cholesterol ratio, determined by insulin resistance and in women additionally by pro-inflammatory state, is of independent predictive value for incident diabetes and weakly for MetS, but not for CHD.
OBJECTIVES: We determined the independent predictive value of serum apolipoprotein (apo) B/LDL-cholesterol ratio for the risk of diabetes, metabolic syndrome (MetS) and coronary heart disease (CHD). DESIGN AND METHODS: Prediction of incident cases was assessed in 2466 adults at 7 years' follow-up. RESULTS:ApoB/LDL ratio was independently associated log-linearly with waist circumference, and, only in men, with HDL-cholesterol in a multivariable regression model. Positive partial correlations existed with fasting insulin, fibrinogen and apo A-I and, only in women, with CRP. Cox regression analyses revealed the two highest apoB/LDL quartiles to be significant determinants of diabetes, at 2-fold RRs, independently of waist circumference, fasting glucose and other confounders. However, apoB/LDL quartiles were not independently associated with CHD in either gender. Only the highest apoB/LDL quartile was associated (RR 1.46) with the development of MetS. Serum apoB/LDL-cholesterol ratio, determined by insulin resistance and in women additionally by pro-inflammatory state, is of independent predictive value for incident diabetes and weakly for MetS, but not for CHD.
Authors: Salma E El-Habashy; Alaa M Nazief; Chris E Adkins; Ming Ming Wen; Amal H El-Kamel; Ahmed M Hamdan; Amira S Hanafy; Tori O Terrell; Afroz S Mohammad; Paul R Lockman; Mohamed Ismail Nounou Journal: Pharm Pat Anal Date: 2014-05
Authors: Monica T Marin; Paul S Dasari; Jeanie B Tryggestad; Christopher E Aston; April M Teague; Kevin R Short Journal: J Diabetes Complications Date: 2015-04-06 Impact factor: 3.219