Literature DB >> 20816396

Gamma-secretase and the intramembrane proteolysis of Notch.

Ellen Jorissen1, Bart De Strooper.   

Abstract

Gamma-secretase is the crucial proteolytic activity that releases the Notch intracellular domain and is therefore a central player in the canonical Notch-signaling transduction pathway. We discuss here briefly the discovery of gamma-secretase and what is known on its structure and function. Recent work also indicates that the assembly and activity of gamma-secretase might be regulated by novel cell biological mechanisms. Finally we explore the recent insight that there are several gamma-secretase complexes in mammalian and discuss possibilities to use gamma-secretase as a drug target in Alzheimer's disease and cancer. Copyright 2010 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20816396     DOI： 10.1016/S0070-2153(10)92006-1

Source DB:  PubMed          Journal:  Curr Top Dev Biol        ISSN： 0070-2153            Impact factor:   4.897


  21 in total

Review 1.  The role of endocytosis in activating and regulating signal transduction.

Authors:  Emma R Andersson
Journal:  Cell Mol Life Sci       Date:  2011-11-24       Impact factor: 9.261

Review 2.  Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin.

Authors:  Johannes Prox; Andrea Rittger; Paul Saftig
Journal:  Exp Brain Res       Date:  2011-11-27       Impact factor: 1.972

Review 3.  Targeting γ-secretase in breast cancer.

Authors:  Jianxun Han; Qiang Shen
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-06-21

4.  Presenilin 2 influences miR146 level and activity in microglia.

Authors:  Suman Jayadev; Amanda Case; Betty Alajajian; Alison J Eastman; Thomas Möller; Gwenn A Garden
Journal:  J Neurochem       Date:  2013-09-30       Impact factor: 5.372

Review 5.  Axonal commissures in the central nervous system: how to cross the midline?

Authors:  Homaira Nawabi; Valérie Castellani
Journal:  Cell Mol Life Sci       Date:  2011-05-03       Impact factor: 9.261

6.  The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.

Authors:  Zhenyi Liu; Eric Brunskill; Barbara Varnum-Finney; Chi Zhang; Andrew Zhang; Patrick Y Jay; Irv Bernstein; Mitsuru Morimoto; Raphael Kopan
Journal:  Development       Date:  2015-06-10       Impact factor: 6.868

Review 7.  Making sense out of missense mutations: Mechanistic dissection of Notch receptors through structure-function studies in Drosophila.

Authors:  Shinya Yamamoto
Journal:  Dev Growth Differ       Date:  2020-01-13       Impact factor: 2.053

8.  The crystal structure of GXGD membrane protease FlaK.

Authors:  Jian Hu; Yi Xue; Sangwon Lee; Ya Ha
Journal:  Nature       Date:  2011-07-17       Impact factor: 49.962

9.  Familial Alzheimer disease presenilin-1 mutations alter the active site conformation of γ-secretase.

Authors:  De-Ming Chau; Christina J Crump; Jennifer C Villa; David A Scheinberg; Yue-Ming Li
Journal:  J Biol Chem       Date:  2012-03-29       Impact factor: 5.157

10.  Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo.

Authors:  Alan D Agulnick; Dana M Ambruzs; Mark A Moorman; Anindita Bhoumik; Rosemary M Cesario; Janice K Payne; Jonathan R Kelly; Carl Haakmeester; Robert Srijemac; Alistair Z Wilson; Justin Kerr; Mauro A Frazier; Evert J Kroon; Kevin A D'Amour
Journal:  Stem Cells Transl Med       Date:  2015-08-24       Impact factor: 6.940
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.