[Advanced oxidation protein products. Part II. The significance of oxidation protein products in the pathomechanism of diabetes and its complications].

Advanced oxidation protein products (AOPP) are derivatives of oxidation-modified albumin which are formed in conditions of intensified oxidative stress. In diabetes the formation of AOPP is induced by intensified glycooxidation processes, oxidant-antioxidant imbalance, and coexisting inflammation. On the other hand, AOPP intensify the metabolic disturbances in diabetes and the progression of its vascular complications. Concentrations of AOPP is significantly higher in diabetes, especially type 2 (about twice) in comparison to healthy people. Changes in AOPP level are connected with poor glycemic control, the chronic state of the disease, dyslipidemia, and diabetic complications, particularly nephropathy. AOPP level is useful marker for monitoring development of diabetic disorders and can be helpful in monitoring of applied therapy.