Radiofrequency ablation of coronary sinus-dependent atrial flutter guided by fractionated mid-diastolic coronary sinus potentials.

BACKGROUND: The efficacy of radiofrequency (RF) ablation of an uncommon coronary sinus (CS)-dependent atrial flutter (AFL) was evaluated using conventional electrophysiological criteria in a highly selected subset of patients with typical and atypical AFL.
METHODS: Fourteen patients with atrial flutter (11 males, mean age 69 ± 9 years) without previous right or left atrial RF ablation were included. Heart disease was present in eight patients. Baseline ECG suggested typical AFL in 12 patients and atypical AFL in two. Mean AFL cycle length was 324 ± 64 ms at the time of RF ablation in the CS. Lateral right atrium activation was counterclockwise (CCW) in 13 patients and clockwise in one. CS activation was CCW in all. Criteria for CS ablation included the presence of CS mid-diastolic fractionated atrial potentials (APs) associated with concealed entrainment with a postpacing interval within 20 ms. Success was defined as termination of AFL and subsequent noninducibility.
RESULTS: The initial target for ablation was the cavotricuspid isthmus (CTI) in 11 patients and the CS with further CTI ablation in three. AP duration at the CS target site was 122 ± 33 ms, spanning 40 ± 12% of the AFL cycle length. CS ablation site was located 1-4 cm from the CS ostium. Ablation was successful in all patients. Mean time to AFL termination during CS ablation was 39 ± 52 s (<20 s in eight patients). No recurrence of ablated arrhythmia occurred during a follow-up of 18 ± 8 months.
CONCLUSIONS: The CS musculature is a critical part of some AFL circuits in patients with typical and atypical AFL. AFL can be terminated in patients with CS or CTI/CS AFL reentrant circuits by targeting CS mid-diastolic fragmented APs.

Introduction

There are few descriptions of macroreentrant atrial circuits in atypical atrial flutter (AFL) in patients who have not undergone previous atrial fibrillation (AF) radiofrequency (RF) ablation in the left atrium [1-5]. Ablation within the coronary sinus (CS) has occasionally been described in these patients [6, 7].

In patients with typical AFL, in whom cavotricuspid isthmus (CTI) ablation is the usual target site, unsuccessful procedures are uncommon [8]. RF ablation in the CS has never been described in these patients for AFL termination.

This study evaluated the efficacy of RF ablation inside the CS using conventional electrophysiological criteria in patients with typical or atypical AFL presenting with the CS as a critical part of the reentrant circuit.

Methods

Study participants

Inclusion involved 14 patients with 12-lead surface ECG AFL [9] in whom a mid-diastolic atrial potential (AP) inside the first centimeters of the CS was found to be part of the circuit after entrainment maneuvers. All patients underwent RF ablation in both the CTI and CS. Exclusion criteria included a previous history of ablation for AF in the left atrium; no patient had had previous ablation session at CTI. Written informed consent was obtained from all patients before enrollment in the study.

Baseline clinical characteristics

Between June 2005 and May 2010, 14 patients (11 males, mean age 69 ± 8 years) were included. These patients represented <1% of all AFL ablations performed within the same time period.

The baseline clinical characteristics of the patients with AFL are summarized in Table 1. Eight patients had underlying structural heart disease (dilated cardiomyopathy in three, previous inferior myocardial infarction in one, aortocoronary bypass grafts in two, mitral valve repair in one, and mitral valve replacement in one). Seven patients had associated episodes of paroxysmal AF. Antiarrhythmic treatment failed to interrupt or prevent AFL (nine patients received amiodarone and one flecainide + amiodarone). Baseline 12-lead surface ECG morphology suggested typical AFL in 12 patients (“sawtooth” negative flutter waves in inferior leads, positive in V1) and atypical AFL in two. AFL was paroxysmal in two patients, persistent in six, and permanent in the remaining six.

Table 1

Characteristics of atrial flutter and procedural data for patients undergoing a first ablation attempt at the cavotricuspid isthmus

N	Pts no.	Age (yrs)	Sex	Cardiac pathology	AA drug	ECG	Clinical type	Associated AF	AFL cycle (ms)	PPI at CTI (ms)	RA lateral wall activation	CS activation	First RF site	AFL stop at CTI	CTI block	AFL induction after CTI ablation	AFL cycle prolongation after CTI ablation
1	JA	51	M	DCM	No	Typical	Persistent	No	220	–	CCW	CCW	CTI	No	–	–	+35
2	DA	76	F	No	Yes	Typical	Persistent	Yes	240	+10	CCW	CCW	CTI	Yes	Yes	Same	+60
3	TM	69	M	No	Yes	Typical	Paroxysmal	Yes	300	+20	CCW	CCW	CTI	Yes	Yes	Different	+100
4	PD	55	M	DCM	Yes	Typical	Permanent	No	320	–	CCW	CCW	CS	–	–	–	–
5	FL	73	M	Myocardial infarction	No	Typical	Persistent	No	210	–	CCW	CCW	CTI	No	–	–	+30
6	BM	65	F	Mitral valve replacement	Yes	Atypical	Permanent	No	240	+20	CW	CCW	CTI	No	–	–	+35
7	CH	64	M	No	Yes	Typical	Persistent	Yes	240	+20	CCW	CCW	CTI	Yes	Yes	Same	+60
8	VR	75	F	No	Yes	Typical	Persistent	Yes	315	+15	CCW	CCW	CTI	Yes	Yes	Same	+45
9	RR	80	M	Mitral valve repair	Yes	Typical	Paroxysmal	yes	240	–	CCW	CCW	CTI	Yes	Yes	Different	+110
10	IJ	79	M	AC bypass	Yes	Typical	Permanent	Yes	240	+0	CCW	CCW	CTI	Yes	Yes	Different	+110
11	RM	69	M	DCM	No	Typical	Persistent	No	330	+20	CCW	CCW	CTI	Yes	Yes	Same	+40
12	VM	70	M	AC bypass	Yes	Atypical	Permanent	No	460	+45	CCW	CCW	CS	–	–	No	–
13	CG	63	M	no	Yes	Typical	Permanent	Yes	250	+10	CCW	CCW	CS	–	–	–	–
14	CC	73	M	no	No	Typical	Permanent	No	220	+10	CCW	CCW	CTI	Yes	Yes	Different	+50

DCM dilated cardiomyopathy, AFL atrial flutter, AA antiarrhythmic, AF atrial fibrillation, CTI cavotricuspid isthmus, RF radiofrequency, PPI postpacing interval, CS coronary sinus, RA right atrium, CW clockwise, CCW counterclockwise

Electrophysiological study

All patients were receiving oral anticoagulants before ablation. All procedures were carried out under mild sedation. Catheters were inserted via the right femoral vein. A steerable mapping catheter (10 poles, 2-8-2 mm electrode interspace) was positioned on the lateral wall of the right atrium in 12 patients, or along the tricuspid annulus (20 poles, 2-8-2 mm electrode interspace) in two; a quadripolar catheter (interspaced 5 mm, MultiCath 4M catheter; Biotronik, Berlin, Germany) was positioned inside the CS. Ablation was carried out using a 4-mm-tip cooled RF catheter (IBI 1641; Saint Jude Medical, connected to a RF generator IBI-1500T8; Saint Jude Medical, St Paul, MN, USA), or an 8-mm-tip RF catheter (Contact; Medtronic Inc., or Safire; Saint Jude Medical, connected to a RF generator Atakr II; Medtronic Inc., Minneapolis, MN, USA).

The CS ostium was located by observing the entry point of the quadripolar mapping catheter into the CS on left and right anterior oblique X-ray views using the ablation catheter in clockwise (CW) rotation to define the CS ostium [6]. The location method was validated in the final patient included in this study (patient 14, Table 1) by retrograde CS angiography was carried out with a coronary artery catheter inserted into the CS (Fig. 1).

Fig. 1

Localization of the coronary sinus (CS) ostium by retrograde CS angiography (patient 14). Clockwise rotation of the ablation catheter defines the CS ostium in a 45° left anterior oblique view. The CS target zone where radiofrequency ablation was applied (1–4 cm from CS ostium) is shown between the two asterisks. LAO left anterior oblique view, ABL ablation catheter, RA 10-pole catheter (interspaced 8-2-8 mm) placed on the lateral wall of the right atrium, CS coronary sinus catheter

Baseline electrophysiological characteristics

The baseline electrophysiological characteristics of the patients with AFL are summarized in Table 1. Mean AFL cycle length before any RF attempt was 273 ± 67 ms. Intracardiac activation pattern at the right atrium (RA) lateral wall was counterclockwise (CCW) in 13 patients, and CW in one. The activation pattern in the CS was CCW in all patients.

Entrainment was performed 20 ms faster than the AFL cycle length. Sites with a postpacing interval (PPI) within 20 ms of the AFL cycle length were defined as being within the circuit. In the beginning of our experience, in three patients with a surface ECG morphology of typical AFL, and later in case no. 9, entrainment at the CTI was not carried out (to avoid AFL interruption or degeneration to AF). Entrainment at the CTI was then performed in 10 patients, of whom nine had a PPI within 20 ms of the baseline cycle length. Entrainment at CTI and CS before RF was made in five patients (cases 6, 7, 8, 13, 14), and in all of them, the PPI was within 20 ms at both sites.

In four patients (cases 6, 7, 8, 14), PPI was within 20 ms of the spontaneous cycle at the CTI (Fig. 2), proximal CS, and Bachman bundle zone, but >50 ms in the mid- and distal CS. In three patients (cases 6, 8, 14), PPI was >50 ms at the mid-interatrial septum, while in case 7, a nonexcitable electrically silent area was found at the interatrial septum. Pacing at different cycle lengths was not performed, either at CTI or CS. All entrainment maneuvers were made before RF attempts ablation.

Fig. 2

Patient with surface ECG typical atrial flutter (AFL) (basic cycle length 250 ms, patient 13). Concealed entrainment showed that both (a) the cavotricuspid isthmus and (b) the proximal coronary sinus (CS) were involved in the AFL circuit. This AFL was successfully interrupted by ablating into the CS. I, II, III, V1 surface ECG leads, ABL ablation catheter, RA 10-pole catheter placed at the lateral wall of the right atrium, CS coronary sinus catheter

Radiofrequency ablation

When initial RF ablation at the CTI failed to interrupt AFL, or when AFL with similar or different ECG surface morphology was still inducible despite the demonstration of a bidirectional CTI block [9], a subsequent attempt was conducted inside the CS. The criteria for targeting and ablating inside the CS were the presence of mid-diastolic coronary sinus fractionated prolonged APs (the upstroke of the surface F-wave, generally the V1 lead, was taken as the reference), associated with concealed entrainment showing a PPI within 20 ms [1, 6] (Figs. 3 and 4).

Fig. 3

Intracardiac recordings at the sites of successful ablation in the coronary sinus (CS). (a, b, c, and d) different types of mesodiastolic CS fragmented polyphasic potentials (the upstroke of the surface F-wave, generally V1 lead, was used as the reference). I, II, III, V1 surface ECG leads, ABL ablation catheter

Fig. 4

Surface ECG typical atrial flutter (AFL) in patient one with basal cycle length 220 ms but CTI ablation was ineffective. Pacing was performed inside the coronary sinus 2 cm from the ostium where a mid-diastolic prolonged fragmented atrial potential was detected, and postpacing interval for entrainment matched the AFL cycle length. AFL was successfully terminated by delivering radiofrequency at this site. I, II, III, V1 surface ECG leads, ABL ablation catheter, RA 10-pole catheter placed at the lateral wall of the right atrium, CS coronary sinus catheter

When RF ablation was delivered at the CTI, maximal power and temperature were 100 W and 60°C for the 8-mm-tip catheter, and 40 W and 40–45°C for the 4-mm-tip cooled catheter. When ablation was carried out inside the CS, maximal power and temperature were 45 W and 55°C for the 8-mm-tip catheter, and 25 W and 40°C for the 4-mm-tip cooled catheter.

In the case of early termination of AFL during RF delivery into the CS (within 20 s), the RF pulse was maintained for 60 s. When AFL was not rapidly terminated, the catheter was moved inside the CS around the zone of positive criteria.

RF ablation was not performed at septal isthmus position.

Acute success was defined as termination of AFL during RF delivery inside the CS, preceded by cycle-length prolongation and subsequent noninducibility. After arrhythmia termination, noninducibility was determined by programmed atrial stimulation, with up to three extrastimuli, or bursts up to 300 ms in cycle length. Induction tests are performed routinely after CTI ablation in our center to improve clinical outcome.

Statistical analysis

Values are presented as the mean±standard deviation or median, as appropriate.

Results

Results are summarized in Fig. 5.

Fig. 5

Diagram illustrating the global results of radiofrequency ablation inside the coronary sinus

The CTI was the first target for ablation in 11 patients. After ablation, AFL persisted in three patients, but the cycle length had increased without ECG, RA, and CS activation pattern modifications. In the other eight of 11 patients, CTI ablation interrupted AFL with a bidirectional CTI block [10], but AFL was still inducible in four patients with the same morphology and RA-CS activation pattern, but increased cycle length; in the other four, AFL was inducible, but the ECG morphology was different, atypical, and the cycle length was prolonged. Globally, in patients with persisting or reinduced AFL despite CTI ablation, the cycle length increased by 61 ± 31 ms.

In three patients, of whom two were among the last patients included (cases 12, 13), the procedure began by directly ablating inside the CS. Of these patients, one had a long PPI at the CTI, and one had a PPI within 20 ms of the AFL basic cycle. AFL was interrupted in all three patients with subsequent AFL noninducibility.

Electrophysiological and procedural data during coronary sinus ablation

The electrophysiological and procedural data for the 14 patients during CS ablation are shown in Table 2.

Table 2

Electrophysiological and procedural data for patients undergoing coronary sinus ablation

N	Pts no.	ECG	AFL cycle (ms)	RA lateral wall activation	CS activation	AP duration into CS (ms)	AP duration/ AFL cycle ratio (%)	AP location from CS ostium (cm)	RF catheter	RF application (n)	Global RF time (s)	Time to AFL interruption (s)	CTI blocka
1	JA	Typical	220	CCW	CCW	120	54	2	8 mm	1	60	15	Yes
2	DA	Typical	320	CCW	CCW	150	47	2	4 mm cooled	3	111	60	Yes
3	TM	Atypical	400	CCW	CCW	100	25	2	4 mm cooled	1	60	8	Yes
4	PD	Typical	320	CCW	CCW	180	56	4	4 mm cooled	1	60	7	Yes
5	FL	Typical	240	CCW	CCW	120	57	2	8 mm	1	60	20	Yes
6	BM	Atypical	275	CW	CCW	110	40	1	8 mm	1	60	15	Yes
7	CH	Typical	300	CCW	CCW	90	30	2	4 mm cooled	4	240	200	Yes
8	VR	Typical	370	CCW	CCW	90	24	1	8 mm	1	60	10	Yes
9	RR	Atypical	350	CCW	CCW	110	31	2–4	8 mm	1	60	30	Yes
10	IJ	Atypical	350	CCW	CCW	100	35	2	8 mm	2	100	60	Yes
11	RM	Typical	370	CCW	CCW	200	54	1	8 mm	1	60	15	Yes
12	VM	Atypical	460	CCW	CCW	100	22	2	8 mm	1	60	10	Yes
13	CG	Typical	300	CCW	CCW	120	44	2	8 mm	2	120	20	Yes
14	CC	Atypical	270	CCW	CCW	120	44	3	4 mm cooled	2	120	80	Yes

AFL atrial flutter, AF atrial fibrillation, CS coronary sinus, RA right atrium, CW clockwise, CCW counterclockwise, AP atrial potential, RF radiofrequency

aCTI block confirmed after AFL interruption at the CTI, successful ablation within the CS after failed AFL interruption at the CTI, and CTI ablation after successful ablation within the CS

At the time of RF ablation inside the CS, surface ECG morphology was typical in eight patients and atypical in six. Typical ECG morphology consisted of “sawtooth” negative F-waves in the inferior leads and positive in V1. Atypical F-waves were characterized by low voltage, generally positive in inferior leads, often notched or biphasic, and generally positive in V1 [11].

Mean AFL cycle length was 324 ± 64 ms. The activation pattern at the RA lateral wall was CCW in 13 patients, and CW in one. The activation pattern in the CS was proximal to distal in all patients. AP duration at the targeted CS site was 122 ± 33 ms, spanning 40 ± 12% of the AFL cycle length. Anatomically, the CS site to which RF was applied was located 1–4 cm from the CS ostium (median 2 cm) [6] (Figs. 1 and 6).

Fig. 6

Patient with typical atrial flutter (AFL) (cycle length 220 ms, patient 14) successfully ablated at the cavotricuspid isthmus. A different atypical AFL with prolonged cycle length (270 ms) was subsequently induced. Ablation of this atypical AFL was successfully performed by targeting a CS mid-diastolic polyphasic atrial potential 3 cm from the ostium. No further arrhythmia was inducible. (a) Catheter location at the final successful site inside the CS confirmed by retrograde CS angiography. (b) Atypical AFL termination inside the CS. LAO left anterior oblique view, I, II, V1 surface ECG leads, ABL ablation catheter, RA 10-pole catheter placed at the lateral wall of the right atrium, CS coronary sinus catheter

RF ablation was performed using an 8-mm-tip catheter in nine patients and a 4-mm-tip cooled catheter in the remaining five. Rapid successful termination of AFL was achieved in all (11 with initial CTI ablation and three with initial ablation inside the CS). The mean number of RF applications into the CS was 1.6 ± 0.9, and global RF time 88 ± 50 s. Time to AFL termination when ablating inside the CS (RF time from the beginning of RF delivery to AFL interruption) was 39 ± 52 s (<20 s in eight patients; Fig. 7). Procedure and X-ray exposure durations were 68 ± 23 min and 12 ± 6 min, respectively.

Fig. 7

Patient with typical surface ECG atrial flutter (AFL, patient 4). Ablation was first directly and successfully performed by targeting a coronary sinus mid-diastolic polyphasic potential 4 cm from the ostium; AFL rapidly terminated within 7 s of applying radiofrequency. Subsequently, no arrhythmia was inducible. The cavotricuspid isthmus was later successively ablated. RF radiofrequency, LAO left anterior oblique view, I, II, III, V1 surface ECG leads, ABL ablation catheter, RA 10-pole catheter placed at the lateral wall of the right atrium, CS coronary sinus catheter

Data for hospital discharge and follow-up are summarized in Table 3.

Table 3

Follow-up

N	Pts no.	AA drugs at hospital discharge	Follow-up (months)	Recurrence
1	JA	No	42	SR
2	DA	Amiodarone	20	SR
3	TM	Amiodarone	22	SR
4	PD	No	21	one episode of AF at 4 mo
5	FL	No	16	SR
6	BM	No	16	SR
7	CH	Amiodarone	14	SR
8	VR	Amiodarone	25	SR
9	RR	Amiodarone	15	SR
10	IJ	Amiodarone	15	SR
11	RM	No	12	SR
12	VM	No	14	SR
13	CG	Amiodarone	14	SR
14	CC	No	9	SR

AA antiarrhythmic, AFL atrial flutter, AF atrial fibrillation, SR sinus rhythm

All patients underwent regular visits to an outpatient clinic at 1-month and at subsequent 3-month intervals. Patients were maintained on anticoagulation therapy for at least 1 month after RF ablation. There was no interruption of antiarrhythmic treatment in the seven patients with a history of AF, while all antiarrhythmic drugs were withdrawn in the other seven.

During a mean follow-up of 18 ± 8 months, no patient had recurrence of the ablated arrhythmia, and only one patient had paroxysmal AF at 4-months follow-up.

Discussion

The CS may be a critical part of the reentrant circuit in patients with typical and atypical AFL. In some cases, both the CTI and CS are involved. These uncommon CS-dependent AFLs can be terminated by targeting mid-diastolic fragmented APs in the first few centimeters of the CS, with a PPI at this site suggesting the CS as an integral part of the circuit. Even if there is no atrial diastole in AFL, the concept of atrial coronary sinus mid-diastolic potential was a useful marker in approaching AFL-failed ablation. These CS-dependent AFLs may mimic typical CTI-dependent AFL [9] and cannot be predicted from ECG or clinical characteristics.

Atypical AFL ablation

In studies of atypical AFL with or without previous ablation for AF in the left atrium [1-5], RF ablation has mainly been performed by two approaches: linear lesions joining two anatomic barriers or silent areas, or both [1, 12] or, second, an electrophysiological approach targeting a critical isthmus presenting with a zone of slow conduction shown to be part of the circuit by pacing maneuvers [3, 4, 6]. Application of RF at this critical isthmus had been performed successfully with RF applications shorter than those usually needed for linear ablation [4, 6].

AFL termination by ablating inside the CS has been previously reported [6, 7]. An atypical AFL circuit involving the CS and left atrial myocardium was described by Olgin et al. [7], with circumferential successful ablation within the distal CS. In the report of Della Bella et al. [6], two successful procedures were performed within the CS at a site where APs exhibited fragmented and prolonged mid-diastolic activity, and where concealed entrainment could be demonstrated.

To our knowledge, this is the first study to include a large number of patients with CS-dependent AFL who were ablated by targeting mid-diastolic APs inside the CS. The procedures were successful after a short RF application time.

Coronary sinus anatomy and fractionated atrial potentials

Anatomic studies [13-16] have shown that the proximal 4 cm of the CS is surrounded by a cuff of striated muscle, which is continuous with the RA myocardium at the CS ostium, and has multiple connections to the left atrial myocardium, and fewer connections to its distal portion. These muscular sleeves are extremely variable in number, location, and thickness. Platonov et al. [17] described a discrete inferior connection between the CS and left atrial myocardium at the level of the right inferior pulmonary vein. This inferior connection may be more prominent than the Bachmann bundle [17, 18].

The genesis of fractionated prolonged APs in the CS is attributable to anisotropic conduction due to its complex anatomy, in combination with conduction slowing during cycle shortening AFL. In our patients, APs were constantly prolonged in duration, spanning a large proportion of the AFL cycle length. The mid-diastolic AP location and AFL termination in a short time argue strongly in favor of a location representing a critical isthmus within the CS musculature. The site of application of RF in the CS was a median distance of 2 cm from the ostium, and a maximum distance of 4 cm, a zone that overlaps the anatomically described extension of the CS muscular cuff [14, 15].

Atrial flutter circuits involving both cavotricuspid isthmus and coronary sinus ablation

In some patients, CTI ablation interrupted AFL, but the same arrhythmia with prolonged cycle length was subsequently reinduced despite the presence of complete CTI block criteria. In other cases, CTI ablation was ineffective, but AFL cycle length increased. However, RF inside the CS targeting mid-diastolic APs was successful for AFL termination and subsequent noninducibility. In one patient with both CTI and CS entrainments, CS ablation as a first attempt was successful in AFL interruption and noninducibility.

Olgin et al. [7] illustrated a case of atypical AFL, in which entrainment mapping suggested a circuit involving the CS exiting in the lateral left atrium, descending the interatrial septum, and reentering the CS. Spaced double potentials throughout the length of the CS were recorded. Successful ablation was accomplished by circumferential RF application within the distal CS. Conversely, APs inside the CS in our patients were always fragmented and polyphasic (no spaced double potentials were recorded), and the successful CS target was more proximal.

Several reports [19, 20] described lower loop reentry as a variant of isthmus-dependent AFLs. In this case, the reentrant circuit turns around the inferior vena cava (IVC), or the IVC and tricuspid annulus in a figure-8-double loop reentry, both types involving also the CS musculature. Thus, CS involvement might suggest a similarity with our patients. Nevertheless, collision front in lateral RA described in lower loop reentry and RF interruption of these AFLs at ICT without needing of adjunctive RF lesions are not in agreement with our observations, making this mechanism improbable in our series. More recently, the same group [21] described in eight patients referred for typical AFL ablation, an intra-isthmus reentry circuit confined to the septal CTI, circling the CS ostium, and showing a collision wave front at the RA wall; in these AFLs, successful ablation required septal CTI RF applications. In our series, no patient presented with these electrophysiological characteristics, and no patient was ablated at the septal CTI.

Surface ECG morphology and endocavitary activation pattern

The correlation between AFL wave morphology and the underlying reentrant circuit is imperfect with infrequent but possible overlap between CTI and non CTI-dependent AFLs [22]. No typical and constant ECG pattern of CS-dependent AFL was identified in this study. Several patients had a “sawtooth” ECG pattern in the inferior leads and positive F wave in V1, while others presented with variable ECG patterns. The intracardiac activation pattern in our patients was also not useful for differentiating CS-dependent AFL from CTI-dependent AFL. The ability to identify patients with CS-dependent AFL before ablation was not possible using surface ECG and endocavitary atrial activation patterns.

Potential risk when ablating in the coronary sinus

Delivery RF energy into the CS is often necessary to achieve complete block in the left mitral isthmus during a left atrial procedure for AF [23, 24]. More recently, the CS has been a target for more extensive RF applications, including AF termination [25, 26]. Ablation of the left atrial isthmus is often completed inside the CS on a line between the left inferior pulmonary vein and mitral annulus [23, 27]. A case was recently reported of acute occlusion of the left circumflex coronary artery during left mitral isthmus linear ablation [28].

In our series, RF was applied in the first 4 cm of the CS, a zone where the wall is thick and arterial vessels are more distal. Additionally, the RF dose was generally low, contributing to the safety of ablation. In previous studies in humans and animals, ablation of epicardial located accessory pathways inside the CS was also shown to be relatively safe [29-33].

Study limitations

This study has several limitations. It included a heterogeneous study population with a complex rhythm disturbance with a lack of detailed mapping and standardization of ablation therapy. Mapping used conventional electrophysiological criteria, entrainment mapping was not systematically and extensively performed at sites other than the CS, and no electroanatomic map was planned. On the other hand, a pragmatic clinical approach was used, which was successful in terms of acute and long-term results.

Clinical implications

The results of this study strongly suggest that mid-diastolic APs in the CS should be evaluated systematically in patients with a “failed” CTI procedure for typical ECG AFL and in some patients with atypical AFL. This strategy may be help in avoiding an unnecessary transseptal approach for atrial left side ablation.

Conclusions

The CS musculature is a critical part of some AFL circuits in patients with typical or atypical AFL. In some cases, both the CTI and CS musculature seem involved in the reentrant circuit. These AFLs can be easily terminated by CTI ablation combined with targeting CS mid-diastolic fragmented APs after demonstrating that the CS is an integral part of the circuit.