BACKGROUND: Approximately 15-20% of patients with osteosarcoma present with detectable metastatic disease and the majority of whom (85%) have pulmonary lesions as the sole site of metastasis. Previous studies have shown that the overall survival rate among patients with localized osteosarcoma without metastatic disease is approximately 60-70% whereas survival rate reduces to 10-30% in patients with metastatic disease. OBJECTIVE: To determine the incidence and characteristic features of pulmonary metastases in a group of osteosarcoma patients and correlate the findings with the prognostic outcome/survival. MATERIALS AND METHODS: Seventy-seven cases of histologically confirmed osteosarcoma were reviewed (47 male, 30 female, mean age 10.9). The site and size of the primary tumour and degrees of chemonecrosis were recorded. Lung metastases were analyzed according to their size, number, distribution and interval from diagnosis. The Kaplan-Meier method was used to analyze the survival probability curve. Significant differences (P < 0.05) were evaluated with the log-rank test for univariate analyses. RESULTS: Seventeen patients had synchronous and 11 had metachronous lung metastases. Sixteen (57%) underwent pulmonary metastasectomy. Nine of sixteen (56%) patients with metastasectomy and 10/12 (83%) patients without metastasectomy died. Poor chemonecrosis was associated with a worse outcome. Number, distribution and timing of lung metastases, but not the size of lung metastases, were of prognostic value for survival. CONCLUSION: Radiological detection of lung metastases is clinically important as it indicates a worse prognosis.
BACKGROUND: Approximately 15-20% of patients with osteosarcoma present with detectable metastatic disease and the majority of whom (85%) have pulmonary lesions as the sole site of metastasis. Previous studies have shown that the overall survival rate among patients with localized osteosarcoma without metastatic disease is approximately 60-70% whereas survival rate reduces to 10-30% in patients with metastatic disease. OBJECTIVE: To determine the incidence and characteristic features of pulmonary metastases in a group of osteosarcomapatients and correlate the findings with the prognostic outcome/survival. MATERIALS AND METHODS: Seventy-seven cases of histologically confirmed osteosarcoma were reviewed (47 male, 30 female, mean age 10.9). The site and size of the primary tumour and degrees of chemonecrosis were recorded. Lung metastases were analyzed according to their size, number, distribution and interval from diagnosis. The Kaplan-Meier method was used to analyze the survival probability curve. Significant differences (P < 0.05) were evaluated with the log-rank test for univariate analyses. RESULTS: Seventeen patients had synchronous and 11 had metachronous lung metastases. Sixteen (57%) underwent pulmonary metastasectomy. Nine of sixteen (56%) patients with metastasectomy and 10/12 (83%) patients without metastasectomy died. Poor chemonecrosis was associated with a worse outcome. Number, distribution and timing of lung metastases, but not the size of lung metastases, were of prognostic value for survival. CONCLUSION: Radiological detection of lung metastases is clinically important as it indicates a worse prognosis.
Authors: M T Han; R L Telander; P C Pairolero; W S Payne; G S Gilchrist; F H Sim; D J Pritchard Journal: J Pediatr Surg Date: 1981-12 Impact factor: 2.545
Authors: Colleen M Costelloe; Homer A Macapinlac; John E Madewell; Nancy E Fitzgerald; Osama R Mawlawi; Eric M Rohren; A Kevin Raymond; Valerae O Lewis; Peter M Anderson; Roland L Bassett; Robyn K Harrell; Edith M Marom Journal: J Nucl Med Date: 2009-03 Impact factor: 10.057
Authors: Ram Mohan Ram Kumar; Matthias Je Arlt; Aleksandar Kuzmanov; Walter Born; Bruno Fuchs Journal: Am J Cancer Res Date: 2015-06-15 Impact factor: 6.166
Authors: Filomena de Nigris; Licciana Zanella; Francesco Cacciatore; Anna De Chiara; Flavio Fazioli; Gennaro Chiappetta; Gaetano Apice; Teresa Infante; Mario Monaco; Raffaele Rossiello; Gaetano De Rosa; Marco Alberghini; Claudio Napoli Journal: BMC Cancer Date: 2011-11-02 Impact factor: 4.430