Literature DB >> 20814421

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

John P Morris1, Sam C Wang, Matthias Hebrok.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt-β-catenin cascades. The creation of mouse models that closely resemble the human disease has provided a platform to better understand when and in which cell types these pathways are misregulated during PDAC development. Here we examine the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt-β-catenin signalling dictate the specification and oncogenic properties of PDAC.

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Year:  2010        PMID： 20814421      PMCID： PMC4085546          DOI： 10.1038/nrc2899

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  131 in total

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Journal:  Clin Cancer Res       Date:  2004-11-01       Impact factor: 12.531

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Journal:  Cancer Res       Date:  1997-03-01       Impact factor: 12.701

3.  Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

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Journal:  J Clin Oncol       Date:  1997-06       Impact factor: 44.544

4.  Activating Smoothened mutations in sporadic basal-cell carcinoma.

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Journal:  Nature       Date:  1998-01-01       Impact factor: 49.962

5.  Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.

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Journal:  Curr Biol       Date:  1997-10-01       Impact factor: 10.834

6.  Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.

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Journal:  Nat Genet       Date:  1994-09       Impact factor: 38.330

7.  Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

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Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

8.  Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells.

Authors:  Diana Romero; Maite Iglesias; Calvin P H Vary; Miguel Quintanilla
Journal:  Carcinogenesis       Date:  2008-02-28       Impact factor: 4.944

9.  Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.

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Journal:  Cancer Res       Date:  1999-10-01       Impact factor: 12.701

10.  Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.

Authors:  Gerhard Regl; Maria Kasper; Harald Schnidar; Thomas Eichberger; Graham W Neill; Michael P Philpott; Harald Esterbauer; Cornelia Hauser-Kronberger; Anna-Maria Frischauf; Fritz Aberger
Journal:  Cancer Res       Date:  2004-11-01       Impact factor: 12.701
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  293 in total

1.  Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling.

Authors:  Ming Quan; Jiujie Cui; Tian Xia; Zhiliang Jia; Dacheng Xie; Daoyan Wei; Suyun Huang; Qian Huang; Shaojiang Zheng; Keping Xie
Journal:  Cancer Res       Date:  2015-10-19       Impact factor: 12.701

2.  High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis.

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3.  Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras.

Authors:  Kinji Asahina; Steven Balog; Edward Hwang; Eugene Moon; Emily Wan; Kaitlin Skrypek; Yibu Chen; Jay Fernandez; Janet Romo; Qihong Yang; Keane Lai; Samuel W French; Hidekazu Tsukamoto
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-11-25       Impact factor: 4.052

Review 4.  Emerging role of the KRAS-PDK1 axis in pancreatic cancer.

Authors:  Riccardo Ferro; Marco Falasca
Journal:  World J Gastroenterol       Date:  2014-08-21       Impact factor: 5.742

5.  Notch Signaling Pathway in Pancreatic Cancer Progression.

Authors:  Jia Ma; Jun Xia; Lucio Miele; Fazlul H Sarkar; Zhiwei Wang
Journal:  Pancreat Disord Ther       Date:  2013-05-30

6.  Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Authors:  Li Ding; Geou-Yarh Liou; Daniel M Schmitt; Peter Storz; Jin-San Zhang; Daniel D Billadeau
Journal:  J Pathol       Date:  2017-07-27       Impact factor: 7.996

7.  Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer.

Authors:  Yi Qin; Qiangsheng Hu; Shunrong Ji; Jin Xu; Weixing Dai; Wensheng Liu; Wenyan Xu; Qiqing Sun; Zheng Zhang; Quanxing Ni; Xianjun Yu; Bo Zhang; Xiaowu Xu
Journal:  Cell Prolif       Date:  2019-04-01       Impact factor: 6.831

8.  Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity.

Authors:  Mei Ding; Xin Wang
Journal:  Oncol Lett       Date:  2017-09-22       Impact factor: 2.967

9.  Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance.

Authors:  Yaqing Zhang; Wei Yan; Meredith A Collins; Filip Bednar; Sabita Rakshit; Bruce R Zetter; Ben Z Stanger; Ivy Chung; Andrew D Rhim; Marina Pasca di Magliano
Journal:  Cancer Res       Date:  2013-10-04       Impact factor: 12.701

10.  Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro.

Authors:  Shao-Jie Chen; Yin-Ting Chen; Lin-Juan Zeng; Qiu-Bo Zhang; Guo-da Lian; Jia-Jia Li; Ke-Ge Yang; Chu-Mei Huang; Ya-Qing Li; Zhong-Hua Chu; Kai-Hong Huang
Journal:  Tumour Biol       Date:  2016-03-08
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