S F Barrington1, J E MacKewn2, P Schleyer2, P K Marsden2, N G Mikhaeel3, W Qian4, P Mouncey5, P Patrick5, B Popova5, P Johnson6, J Radford7, M J O'Doherty2. 1. Division of Imaging Sciences, PET Imaging Centre at St Thomas', Kings College London, London. Electronic address: sally.barrington@kcl.ac.uk. 2. Division of Imaging Sciences, PET Imaging Centre at St Thomas', Kings College London, London. 3. Department of Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London. 4. MRC Clinical Trials Unit, London. 5. Cancer Research UK and UCL Clinical Trials Centre, London. 6. Cancer Research UK Clinical Centre, Southampton. 7. The Christie NHS Foundation Trust, Manchester; University of Manchester, Manchester, UK.
Abstract
BACKGROUND: Multicentre trials are required to determine how [fluorine-18]-2-fluoro-2-deoxy-D-glucose-positron emission tomography imaging can guide cancer treatment. Consistency in quality control (QC), scan acquisition and reporting is mandatory for high-quality results, which are comparable across sites. METHODS: A national positron emission tomography (PET) clinical trials network (CTN) has been set up with a 'core laboratory' to coordinate QC and interpret scans. The CTN is involved in trials in Hodgkin's lymphoma [Randomised Phase III trial to determine the role of FDG-PET Imaging in Clinical Stages IA/IIA Hodgkin's Disease (RAPID) and Randomised Phase III trial to assess response adapted therapy using FDG-PET imaging in patients with newly diagnosed, advanced Hodgkin lymphoma (RATHL)] and diffuse large B-cell lymphoma [Blinded evaluation of prognostic value of FDG-PET after 2 cycles of chemotherapy in diffuse large B-cell Non-Hodgkins Lymphoma, a sub-study of the R-CHOP-21 vs R-CHOP-14 trial (R-CHOP PET substudy)]. Approval to join requires scanner validation and agreement to follow a standard QC protocol. Scans are transferred to the core laboratory and reported centrally according to predetermined criteria. RESULTS: The qualification procedure was carried out on 15 scanners. All scanners were able to demonstrate the necessary quantitative accuracy, and following modification of image reconstruction where necessary, scanners demonstrated comparable recovery coefficients (RCs) indicating similar performance. The average RC (±1 standard deviation) was 0.56 ± 0.095 for the 13-mm sphere. Reports from 444 of 473 (94%) patients in RAPID and 67 of 73 (92%) patients in RATHL were available for randomisation of therapy. CONCLUSIONS: The CTN has enabled consistent quality assured PET results to be obtained from multiple centres in time for clinical decision making. The results of trials will be significantly strengthened by this system.
BACKGROUND: Multicentre trials are required to determine how [fluorine-18]-2-fluoro-2-deoxy-D-glucose-positron emission tomography imaging can guide cancer treatment. Consistency in quality control (QC), scan acquisition and reporting is mandatory for high-quality results, which are comparable across sites. METHODS: A national positron emission tomography (PET) clinical trials network (CTN) has been set up with a 'core laboratory' to coordinate QC and interpret scans. The CTN is involved in trials in Hodgkin's lymphoma [Randomised Phase III trial to determine the role of FDG-PET Imaging in Clinical Stages IA/IIA Hodgkin's Disease (RAPID) and Randomised Phase III trial to assess response adapted therapy using FDG-PET imaging in patients with newly diagnosed, advanced Hodgkin lymphoma (RATHL)] and diffuse large B-cell lymphoma [Blinded evaluation of prognostic value of FDG-PET after 2 cycles of chemotherapy in diffuse large B-cell Non-Hodgkins Lymphoma, a sub-study of the R-CHOP-21 vs R-CHOP-14 trial (R-CHOP PET substudy)]. Approval to join requires scanner validation and agreement to follow a standard QC protocol. Scans are transferred to the core laboratory and reported centrally according to predetermined criteria. RESULTS: The qualification procedure was carried out on 15 scanners. All scanners were able to demonstrate the necessary quantitative accuracy, and following modification of image reconstruction where necessary, scanners demonstrated comparable recovery coefficients (RCs) indicating similar performance. The average RC (±1 standard deviation) was 0.56 ± 0.095 for the 13-mm sphere. Reports from 444 of 473 (94%) patients in RAPID and 67 of 73 (92%) patients in RATHL were available for randomisation of therapy. CONCLUSIONS: The CTN has enabled consistent quality assured PET results to be obtained from multiple centres in time for clinical decision making. The results of trials will be significantly strengthened by this system.
Authors: Lucy C Pike; Christopher M Thomas; Teresa Guerrero-Urbano; Andriana Michaelidou; Tony Greener; Elizabeth Miles; David Eaton; Sally F Barrington Journal: Br J Radiol Date: 2019-08-23 Impact factor: 3.039
Authors: Sally F Barrington; Elizabeth H Phillips; Nicholas Counsell; Barry Hancock; Ruth Pettengell; Peter Johnson; William Townsend; Dominic Culligan; Bilyana Popova; Laura Clifton-Hadley; Andrew McMillan; Peter Hoskin; Michael J O'Doherty; Tim Illidge; John Radford Journal: J Clin Oncol Date: 2019-05-21 Impact factor: 44.544
Authors: Sally F Barrington; N George Mikhaeel; Lale Kostakoglu; Michel Meignan; Martin Hutchings; Stefan P Müeller; Lawrence H Schwartz; Emanuele Zucca; Richard I Fisher; Judith Trotman; Otto S Hoekstra; Rodney J Hicks; Michael J O'Doherty; Roland Hustinx; Alberto Biggi; Bruce D Cheson Journal: J Clin Oncol Date: 2014-09-20 Impact factor: 44.544
Authors: Bruce D Cheson; Richard I Fisher; Sally F Barrington; Franco Cavalli; Lawrence H Schwartz; Emanuele Zucca; T Andrew Lister Journal: J Clin Oncol Date: 2014-09-20 Impact factor: 44.544
Authors: Joshua S Scheuermann; Janet S Reddin; Adam Opanowski; Paul E Kinahan; Barry A Siegel; Lalitha K Shankar; Joel S Karp Journal: J Nucl Med Date: 2017-03-02 Impact factor: 10.057
Authors: Georg Kuhnert; Ronald Boellaard; Sergej Sterzer; Deniz Kahraman; Matthias Scheffler; Jürgen Wolf; Markus Dietlein; Alexander Drzezga; Carsten Kobe Journal: Eur J Nucl Med Mol Imaging Date: 2015-08-18 Impact factor: 9.236