Literature DB >> 20813434

Antihypertensive activity of newer 1,4-dihydro-5-pyrimidine carboxamides: synthesis and pharmacological evaluation.

Ozair Alam1, Suroor A Khan, Nadeem Siddiqui, Waquar Ahsan, Suraj P Verma, Sadaf J Gilani.   

Abstract

A number of 5-(4-substituted phenyl)-2-(substituted benzylsulfanyl)-4-(substituted phenyl)-6-methyl-1,4-dihydro-5-pyrimidine carboxamides (1-30) were designed and synthesized keeping in view the structural requirements as suggested in the pharmacophore model for antihypertensive activity. All the synthesized compounds were tested for antihypertensive activity by non-invasive blood pressure (NIBP) measurements (tail-cuff method) in rats. Almost all the tested compounds displayed considerable decrease in the blood pressure as compared to control. Thirteen compounds showed significant antihypertensive activity comparable to the standard drug nifedipine.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20813434     DOI： 10.1016/j.ejmech.2010.08.022

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Development of energetic pharmacophore for the designing of 1,2,3,4-tetrahydropyrimidine derivatives as selective cyclooxygenase-2 inhibitors.

Authors:  Deepak Lokwani; Reecha Shah; Santosh Mokale; Padma Shastry; Devanand Shinde
Journal:  J Comput Aided Mol Des       Date:  2012-01-05       Impact factor: 3.686

2.  Structural and theoretical studies of 4-chloro-2-methyl-6-oxo-3,6-dideuteropyrimidin-1-ium chloride (d 6).

Authors:  Ray J Butcher; Andrew P Purdy; Sean A Fischer; Daniel Gunlycke
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-19

3.  Crystal structure of ethyl 2-cyano-3-[(1-eth-oxy-ethyl-idene)amino]-5-(3-meth-oxy-phen-yl)-7-methyl-5H-1,3-thia-zolo[3,2-a]pyrimidine-6-carboxyl-ate.

Authors:  M S Krishnamurthy; Noor Shahina Begum
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-03-25

4.  Crystal structure of ethyl 2-(2-fluoro-benzyl-idene)-5-(4-fluoro-phen-yl)-7-methyl-3-oxo-2,3-di-hydro-5H-1,3-thia-zolo[3,2-a]pyrimidine-6-carb-oxy-late.

Authors:  M S Krishnamurthy; Noor Shahina Begum
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-11-19

5.  Synthesis, Biological Evaluation and Molecular Docking Study of 2-Substituted-4,6-Diarylpyrimidines as α-Glucosidase Inhibitors.

Authors:  Zipeng Gong; Zhenzhen Xie; Jie Qiu; Guangcheng Wang
Journal:  Molecules       Date:  2017-10-30       Impact factor: 4.411

Review 6.  Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review.

Authors:  Ramandeep Kaur; Sandeep Chaudhary; Kapil Kumar; Manish K Gupta; Ravindra K Rawal
Journal:  Eur J Med Chem       Date:  2017-03-19       Impact factor: 6.514

7.  Synthesis, crystal structure and antibacterial studies of dihydropyrimidines and their regioselectively oxidized products.

Authors:  Alakbar E Huseynzada; Christian Jelch; Haji Vahid N Akhundzada; Sarra Soudani; Cherif Ben Nasr; Aygun Israyilova; Filippo Doria; Ulviyya A Hasanova; Rana F Khankishiyeva; Mauro Freccero
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

8.  3-(Propylthio)propane-1-sulfonic acid immobilized on functionalized magnetic nanoparticles as an efficient catalyst for one-pot synthesis of dihydrotetrazolo[1,5-a]pyrimidine and tetrahydrotetrazolo[5,1-b]quinazolinone derivatives.

Authors:  Fatemeh Karimi; Behnaz Tighsazzadeh; Beheshteh Asadi; Iraj Mohammadpoor-Baltork; Mahsa Layeghi; Valiollah Mirkhani; Shahram Tangestaninejad; Majid Moghadam
Journal:  RSC Adv       Date:  2022-08-10       Impact factor: 4.036

9.  Crystal structure of 2-acetyl-5-(3-methoxyphenyl)-3,7-dimethyl-5H-1,3-thiazolo[3,2-a]pyrimidine-6-carboxylate.

Authors:  N L Prasad; M S Krishnamurthy; H Nagarajaiah; Noor Shahina Begum
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-29
  9 in total

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