Literature DB >> 20812672

Imidazole-catalyzed monoacylation of symmetrical diamines.

Sanjeev K Verma1, B N Acharya, M P Kaushik.   

Abstract

An imidazole-catalyzed protocol for monoacylation of symmetrical diamines has been developed. The protocol gave selective monoacylation of aliphatic (cyclic and acyclic) primary and secondary diamines. In the reaction, imidazole acts as both catalyst and a leaving group. Different monoacylated piperazines and other diamines were synthesized at room temperature in an ethanol/water solvent system.

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Year:  2010        PMID： 20812672     DOI： 10.1021/ol101604q

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Synthesis, dynamic NMR characterization and XRD studies of novel N,N'-substituted piperazines for bioorthogonal labeling.

Authors:  Constantin Mamat; Marc Pretze; Matthew Gott; Martin Köckerling
Journal:  Beilstein J Org Chem       Date:  2016-11-21       Impact factor: 2.883

2.  Simplified Procedure for General Synthesis of Monosubstituted Piperazines-From a Batch Reaction Vessel to a Flow (Microwave) Reactor.

Authors:  Dana Němečková; Eva Havránková; Jan Šimbera; Richard Ševčík; Pavel Pazdera
Journal:  Molecules       Date:  2020-05-06       Impact factor: 4.411

3.  NMR-based investigations of acyl-functionalized piperazines concerning their conformational behavior in solution.

Authors:  Robert Wodtke; Janine Steinberg; Martin Köckerling; Reik Löser; Constantin Mamat
Journal:  RSC Adv       Date:  2018-12-06       Impact factor: 4.036
  3 in total

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