BACKGROUND: Prostate cancer is the most common type of cancer among men. OBJECTIVES: To investigate the trace elements (Se, Zn, Cu and Cd) and vitamin E status of some Nigerian prostate cancer (PCa) patients relative to their prostate-specific antigen (PSA) values. METHODS: Prostate cancer patients were assigned into groups 1, 2 and 3 with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. RESULTS: The results showed that the levels of whole blood superoxide dismutase (SOD) and serum Se and Zn were significantly lower (p< 0.05) in the PCa patients. Specifically, levels of SOD, Se and Zn decreased by 67%, 30% and 35%; 70%, 52% and 41%; 81%, 58% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. There were no significant differences (p> 0.05) in levels of Cu and Cd. Serum Cu/ Zn ratio were significantly higher in PCa patients. The Cu/ Zn ratios were 1: 1.2: 1.3 for subjects in groups 1, 2 and 3, respectively. Vitamin E levels in PCa patients were significantly lower and followed the order; normal > PSA (5-10) > PSA (11-20) > PSA (> 20). CONCLUSIONS: Deficiency of vitamin E, Zn and Se may be risk factors for development of PCa.
BACKGROUND:Prostate cancer is the most common type of cancer among men. OBJECTIVES: To investigate the trace elements (Se, Zn, Cu and Cd) and vitamin E status of some Nigerian prostate cancer (PCa) patients relative to their prostate-specific antigen (PSA) values. METHODS:Prostate cancerpatients were assigned into groups 1, 2 and 3 with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. RESULTS: The results showed that the levels of whole blood superoxide dismutase (SOD) and serum Se and Zn were significantly lower (p< 0.05) in the PCa patients. Specifically, levels of SOD, Se and Zn decreased by 67%, 30% and 35%; 70%, 52% and 41%; 81%, 58% and 47%, in subjects with PSA of 5-10 ng/ml, 11-20 ng/ml and > 20 ng/ml, respectively. There were no significant differences (p> 0.05) in levels of Cu and Cd. Serum Cu/ Zn ratio were significantly higher in PCa patients. The Cu/ Zn ratios were 1: 1.2: 1.3 for subjects in groups 1, 2 and 3, respectively. Vitamin E levels in PCa patients were significantly lower and followed the order; normal > PSA (5-10) > PSA (11-20) > PSA (> 20). CONCLUSIONS: Deficiency of vitamin E, Zn and Se may be risk factors for development of PCa.
Authors: O P Heinonen; D Albanes; J Virtamo; P R Taylor; J K Huttunen; A M Hartman; J Haapakoski; N Malila; M Rautalahti; S Ripatti; H Mäenpää; L Teerenhovi; L Koss; M Virolainen; B K Edwards Journal: J Natl Cancer Inst Date: 1998-03-18 Impact factor: 13.506
Authors: Anna J Duffield-Lillico; Elizabeth H Slate; Mary E Reid; Bruce W Turnbull; Patricia A Wilkins; Gerald F Combs; H Kim Park; Earl G Gross; Gloria F Graham; M Suzanne Stratton; James R Marshall; Larry C Clark Journal: J Natl Cancer Inst Date: 2003-10-01 Impact factor: 13.506
Authors: Alkan Hacer Iynem; Ayşe Zeynep Alademir; Can Obek; Ali Riza Kural; Dildar Konukoğlu; Tülay Akçay Journal: Int Urol Nephrol Date: 2004 Impact factor: 2.370
Authors: Anwar Ali; Muhammad Faisal Manzoor; Nazir Ahmad; Rana Muhammad Aadil; Hong Qin; Rabia Siddique; Sakhawat Riaz; Arslan Ahmad; Sameh A Korma; Waseem Khalid; Liu Aizhong Journal: Front Nutr Date: 2022-07-22