Literature DB >> 20811445

Alzheimer's disease: Selectively tuning gamma-secretase.

Peter St George-Hyslop, Gerold Schmitt-Ulms.   

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Year:  2010        PMID: 20811445     DOI: 10.1038/467036a

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


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  14 in total

1.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Authors:  G Yu; M Nishimura; S Arawaka; D Levitan; L Zhang; A Tandon; Y Q Song; E Rogaeva; F Chen; T Kawarai; A Supala; L Levesque; H Yu; D S Yang; E Holmes; P Milman; Y Liang; D M Zhang; D H Xu; C Sato; E Rogaev; M Smith; C Janus; Y Zhang; R Aebersold; L S Farrer; S Sorbi; A Bruni; P Fraser; P St George-Hyslop
Journal:  Nature       Date:  2000-09-07       Impact factor: 49.962

2.  Nicastrin binds to membrane-tethered Notch.

Authors:  F Chen; G Yu; S Arawaka; M Nishimura; T Kawarai; H Yu; A Tandon; A Supala; Y Q Song; E Rogaeva; P Milman; C Sato; C Yu; C Janus; J Lee; L Song; L Zhang; P E Fraser; P H St George-Hyslop
Journal:  Nat Cell Biol       Date:  2001-08       Impact factor: 28.824

3.  The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons.

Authors:  Amantha Thathiah; Kurt Spittaels; Marcel Hoffmann; Mik Staes; Adrian Cohen; Katrién Horré; Mieke Vanbrabant; Frea Coun; Veerle Baekelandt; André Delacourte; David F Fischer; Dirk Pollet; Bart De Strooper; Pascal Merchiers
Journal:  Science       Date:  2009-02-13       Impact factor: 47.728

4.  Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.

Authors:  Gen He; Wenjie Luo; Peng Li; Christine Remmers; William J Netzer; Joseph Hendrick; Karima Bettayeb; Marc Flajolet; Fred Gorelick; Lawrence P Wennogle; Paul Greengard
Journal:  Nature       Date:  2010-09-02       Impact factor: 49.962

5.  Substrate-targeting gamma-secretase modulators.

Authors:  Thomas L Kukar; Thomas B Ladd; Maralyssa A Bann; Patrick C Fraering; Rajeshwar Narlawar; Ghulam M Maharvi; Brent Healy; Robert Chapman; Alfred T Welzel; Robert W Price; Brenda Moore; Vijayaraghavan Rangachari; Bernadette Cusack; Jason Eriksen; Karen Jansen-West; Christophe Verbeeck; Debra Yager; Christopher Eckman; Wenjuan Ye; Sarah Sagi; Barbara A Cottrell; Justin Torpey; Terrone L Rosenberry; Abdul Fauq; Michael S Wolfe; Boris Schmidt; Dominic M Walsh; Edward H Koo; Todd E Golde
Journal:  Nature       Date:  2008-06-12       Impact factor: 49.962

6.  gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Authors:  Mako Takami; Yu Nagashima; Yoshihisa Sano; Seiko Ishihara; Maho Morishima-Kawashima; Satoru Funamoto; Yasuo Ihara
Journal:  J Neurosci       Date:  2009-10-14       Impact factor: 6.167

7.  aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

Authors:  Ross Francis; Garth McGrath; Jianhuan Zhang; David A Ruddy; Mary Sym; Javier Apfeld; Monique Nicoll; Mark Maxwell; Bing Hai; Michael C Ellis; Annette L Parks; Wei Xu; Jinhe Li; Mark Gurney; Richard L Myers; Carol S Himes; Ronald Hiebsch; Cara Ruble; Jeffrey S Nye; Daniel Curtis
Journal:  Dev Cell       Date:  2002-07       Impact factor: 12.270

8.  Gleevec inhibits beta-amyloid production but not Notch cleavage.

Authors:  William J Netzer; Fei Dou; Dongming Cai; Darren Veach; Stephanie Jean; Yueming Li; William G Bornmann; Bayard Clarkson; Huaxi Xu; Paul Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-01       Impact factor: 11.205

9.  TMP21 transmembrane domain regulates gamma-secretase cleavage.

Authors:  Raphaëlle Pardossi-Piquard; Christopher Böhm; Fusheng Chen; Soshi Kanemoto; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
Journal:  J Biol Chem       Date:  2009-08-25       Impact factor: 5.157

10.  Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Authors:  R Sherrington; E I Rogaev; Y Liang; E A Rogaeva; G Levesque; M Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; S Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; R E Tanzi; A D Roses; P E Fraser; J M Rommens; P H St George-Hyslop
Journal:  Nature       Date:  1995-06-29       Impact factor: 49.962

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  2 in total

1.  Peering inside Alzheimer's brains.

Authors:  Gunjan Sinha
Journal:  Nat Biotechnol       Date:  2011-05       Impact factor: 54.908

2.  Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Authors:  Yi Li; Stephen Hsueh-Jeng Lu; Ching-Ju Tsai; Christopher Bohm; Seema Qamar; Roger B Dodd; William Meadows; Amy Jeon; Adam McLeod; Fusheng Chen; Muriel Arimon; Oksana Berezovska; Bradley T Hyman; Taisuke Tomita; Takeshi Iwatsubo; Christopher M Johnson; Lindsay A Farrer; Gerold Schmitt-Ulms; Paul E Fraser; Peter H St George-Hyslop
Journal:  Structure       Date:  2013-11-07       Impact factor: 5.006

  2 in total

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