Literature DB >> 20810841

Relationship between nonstructural protein 1 detection and plasma virus load in Dengue patients.

Laurent Thomas1, Fatiha Najioullah, Olivier Verlaeten, Jenny Martial, Ségolène Brichler, Stéphane Kaidomar, Victor Moravie, André Cabié, Raymond Césaire.   

Abstract

We report data from a prospective observational study performed in Martinique during a co-epidemic of dengue virus serotype 2 (DENV-2) and serotype 4 (DENV-4). Among 70 serum samples from patients with DENV-2 (n = 21) or DENV-4 (n = 49) infections, 47 (67.1%) were positive for dengue nonstructural protein 1 (NS1). Antigenemia correlated with plasma virus load and was independent of immune status and the time of sampling. Increased viremia 4-6 days after onset of illness was associated with NS1 positivity, secondary infection, and severe disease. Testing for NS1 could help identify the potentially most severely ill patients during the critical phase of dengue.

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Year:  2010        PMID： 20810841      PMCID： PMC2929072          DOI： 10.4269/ajtmh.2010.10-0138

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  17 in total

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Authors:  Pei-Yun Shu; Li-Kuang Chen; Shu-Fen Chang; Yi-Yun Yueh; Ling Chow; Li-Jung Chien; Chuan Chin; Ting-Hsiang Lin; Jyh-Hsiung Huang
Journal:  Clin Diagn Lab Immunol       Date:  2003-07

2.  Evaluation of immunoglobulin M and G capture enzyme-linked immunosorbent assay Panbio kits for diagnostic dengue infections.

Authors:  Susana Vazquez; Greg Hafner; Didye Ruiz; Naifi Calzada; Maria G Guzman
Journal:  J Clin Virol       Date:  2007-05-22       Impact factor: 3.168

3.  An antigen capture enzyme-linked immunosorbent assay reveals high levels of the dengue virus protein NS1 in the sera of infected patients.

Authors:  P R Young; P A Hilditch; C Bletchly; W Halloran
Journal:  J Clin Microbiol       Date:  2000-03       Impact factor: 5.948

4.  Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

Authors:  D W Vaughn; S Green; S Kalayanarooj; B L Innis; S Nimmannitya; S Suntayakorn; T P Endy; B Raengsakulrach; A L Rothman; F A Ennis; A Nisalak
Journal:  J Infect Dis       Date:  2000-01       Impact factor: 5.226

Review 5.  Dengue virus pathogenesis: an integrated view.

Authors:  Byron E E Martina; Penelope Koraka; Albert D M E Osterhaus
Journal:  Clin Microbiol Rev       Date:  2009-10       Impact factor: 26.132

6.  High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.

Authors:  Daniel H Libraty; Paul R Young; Darren Pickering; Timothy P Endy; Siripen Kalayanarooj; Sharone Green; David W Vaughn; Ananda Nisalak; Francis A Ennis; Alan L Rothman
Journal:  J Infect Dis       Date:  2002-09-16       Impact factor: 5.226

7.  Evaluation of an NS1 antigen detection for diagnosis of acute dengue infection in patients with acute febrile illness.

Authors:  Keswadee Lapphra; Anyarit Sangcharaswichai; Kulkanya Chokephaibulkit; Surapee Tiengrim; Wirongrong Piriyakarnsakul; Tipa Chakorn; Sutee Yoksan; Luksamee Wattanamongkolsil; Visanu Thamlikitkul
Journal:  Diagn Microbiol Infect Dis       Date:  2008-01-11       Impact factor: 2.803

8.  Detection of immune-complex-dissociated nonstructural-1 antigen in patients with acute dengue virus infections.

Authors:  Penelopie Koraka; Chantal P Burghoorn-Maas; Andrew Falconar; Tatty E Setiati; Kiss Djamiatun; Jan Groen; Albert D M E Osterhaus
Journal:  J Clin Microbiol       Date:  2003-09       Impact factor: 5.948

9.  Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses.

Authors:  Vu Ty Hang; Nguyen Minh Nguyet; Dinh The Trung; Vianney Tricou; Sutee Yoksan; Nguyen Minh Dung; Tran Van Ngoc; Tran Tinh Hien; Jeremy Farrar; Bridget Wills; Cameron P Simmons
Journal:  PLoS Negl Trop Dis       Date:  2009-01-20

10.  Evaluation of two new commercial tests for the diagnosis of acute dengue virus infection using NS1 antigen detection in human serum.

Authors:  Philippe Dussart; Laure Petit; Bhety Labeau; Laetitia Bremand; Alexandre Leduc; David Moua; Séverine Matheus; Laurence Baril
Journal:  PLoS Negl Trop Dis       Date:  2008-08-20
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  22 in total

1.  NS 1 lasts longer than the dengue virus nucleic acid in the clinically suspected patients with dengue fever and dengue haemorrhagic fever.

Authors:  Nadeera Sirisena; Faseeha Noordeen; LakKumar Fernando
Journal:  Virusdisease       Date:  2017-09-20

2.  Is Reactive Dengue NS1Antigen Test a Warning Call for Hospital Admissions?

Authors:  Sriram Pothapregada; Banupriya Kamalakannan; Mahalakshmy Thulasingam; Srinivasan Sampath
Journal:  J Clin Diagn Res       Date:  2016-04-01

3.  Simultaneous Detection of Dengue NS1 Antigen, IgM plus IgG and Platelet Enumeration during an Outbreak.

Authors:  Subhash C Arya; Nirmala Agarwal; Satibh C Parikh; Shekhar Agarwal
Journal:  Sultan Qaboos Univ Med J       Date:  2011-10-25

4.  Evaluation of the Dengue NS1 Ag Strip® for detection of dengue virus antigen in Aedes aegypti (Diptera: Culicidae).

Authors:  Cheong-Huat Tan; Pei-Sze Jeslyn Wong; Mei-Zhi Irene Li; Indra Vythilingam; Lee-Ching Ng
Journal:  Vector Borne Zoonotic Dis       Date:  2011-03-11       Impact factor: 2.133

5.  Determination of viremia and concentration of circulating nonstructural protein 1 in patients infected with dengue virus in Mexico.

Authors:  Sergio I de la Cruz-Hernández; Hilario Flores-Aguilar; Silvia González-Mateos; Irma López-Martinez; Celia Alpuche-Aranda; Juan E Ludert; Rosa M del Angel
Journal:  Am J Trop Med Hyg       Date:  2013-01-21       Impact factor: 2.345

6.  A genetic and pathologic study of a DENV2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent mice.

Authors:  Jaime Henrique Amorim; Raíza Sales Pereira Bizerra; Rúbens Prince dos Santos Alves; Maria Elisabete Sbrogio-Almeida; José Eduardo Levi; Margareth Lara Capurro; Luís Carlos de Souza Ferreira
Journal:  PLoS One       Date:  2012-09-13       Impact factor: 3.240

7.  Variation in vector competence for dengue viruses does not depend on mosquito midgut binding affinity.

Authors:  Jonathan Cox; Heidi E Brown; Rebeca Rico-Hesse
Journal:  PLoS Negl Trop Dis       Date:  2011-05-17

Review 8.  Animal models of dengue virus infection.

Authors:  Simona Zompi; Eva Harris
Journal:  Viruses       Date:  2012-01-09       Impact factor: 5.048

9.  Dengue NS1 antigen contributes to disease severity by inducing interleukin (IL)-10 by monocytes.

Authors:  T N Adikari; L Gomes; N Wickramasinghe; M Salimi; N Wijesiriwardana; A Kamaladasa; N L A Shyamali; G S Ogg; G N Malavige
Journal:  Clin Exp Immunol       Date:  2016-01-19       Impact factor: 4.330

10.  Value of Routine Dengue Diagnostic Tests in Urine and Saliva Specimens.

Authors:  Anne-Claire Andries; Veasna Duong; Sowath Ly; Julien Cappelle; Kim Srorn Kim; Patrich Lorn Try; Sopheaktra Ros; Sivuth Ong; Rekol Huy; Paul Horwood; Marie Flamand; Anavaj Sakuntabhai; Arnaud Tarantola; Philippe Buchy
Journal:  PLoS Negl Trop Dis       Date:  2015-09-25
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