Literature DB >> 20810780

Dabigatran inhibits Staphylococcus aureus coagulase activity.

Thomas Vanassche1, Jan Verhaegen, Willy E Peetermans, Marc F Hoylaerts, Peter Verhamme.   

Abstract

The ability of Staphylococcus aureus to clot plasma through conformational activation of prothrombin by staphylocoagulase is used to distinguish S. aureus from coagulase-negative staphylococci. We show that while the direct thrombin inhibitor dabigatran inhibits staphylocoagulase activity, the clinical use of dabigatran etexilate is not expected to interfere with direct tube coagulase testing.

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Year:  2010        PMID： 20810780      PMCID： PMC3020810          DOI： 10.1128/JCM.00896-10

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  24 in total

1.  Purification and properties of staphylocoagulase.

Authors:  B M Bas; A D Muller; H C Hemker
Journal:  Biochim Biophys Acta       Date:  1975-01-30

2.  Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.

Authors:  Rainer Friedrich; Peter Panizzi; Pablo Fuentes-Prior; Klaus Richter; Ingrid Verhamme; Patricia J Anderson; Shun-Ichiro Kawabata; Robert Huber; Wolfram Bode; Paul E Bock
Journal:  Nature       Date:  2003-10-02       Impact factor: 49.962

Review 3.  Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity.

Authors:  Joanne van Ryn; Joachim Stangier; Sebastian Haertter; Karl-Heinz Liesenfeld; Wolfgang Wienen; Martin Feuring; Andreas Clemens
Journal:  Thromb Haemost       Date:  2010-03-29       Impact factor: 5.249

4.  Anticoagulant carryover may influence clot formation in direct tube coagulase tests from blood cultures.

Authors:  Kerry Varettas; Chinmoy Mukerjee; Peter C Taylor
Journal:  J Clin Microbiol       Date:  2005-09       Impact factor: 5.948

5.  Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning.

Authors:  P Jonsson; M Lindberg; I Haraldsson; T Wadström
Journal:  Infect Immun       Date:  1985-09       Impact factor: 3.441

6.  Dabigatran versus warfarin in the treatment of acute venous thromboembolism.

Authors:  Sam Schulman; Clive Kearon; Ajay K Kakkar; Patrick Mismetti; Sebastian Schellong; Henry Eriksson; David Baanstra; Janet Schnee; Samuel Z Goldhaber
Journal:  N Engl J Med       Date:  2009-12-10       Impact factor: 91.245

7.  Rapid identification of Staphylococcus aureus from blood culture bottles by a classic 2-hour tube coagulase test.

Authors:  C L McDonald; K Chapin
Journal:  J Clin Microbiol       Date:  1995-01       Impact factor: 5.948

8.  Effect of highly purified coagulase and culture filtrate on virulence and immunity of a coagulase-negative mutant of staphylococcus aureus BB.

Authors:  N Hasegawa; I Kondo; S Hoshina; K Kurosaka; H Igarashi
Journal:  Infect Immun       Date:  1983-03       Impact factor: 3.441

9.  Pharmacoeconomic analysis of microbiologic techniques for differentiating staphylococci directly from blood culture bottles.

Authors:  Elizabeth D Hermsen; Sara S Shull; Donald G Klepser; Peter C Iwen; Amy Armbrust; Jodi Garrett; Alison G Freifeld; Mark E Rupp
Journal:  J Clin Microbiol       Date:  2008-07-09       Impact factor: 5.948

10.  The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects.

Authors:  Joachim Stangier; Karin Rathgen; Hildegard Stähle; Dietmar Gansser; Willy Roth
Journal:  Br J Clin Pharmacol       Date:  2007-05-15       Impact factor: 4.335
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  16 in total

Review 1.  Exploring Staphylococcus aureus pathways to disease for vaccine development.

Authors:  Andrea DeDent; Hwan Keun Kim; Dominique Missiakas; Olaf Schneewind
Journal:  Semin Immunopathol       Date:  2011-12-01       Impact factor: 9.623

2.  The role of hemostasis in infective endocarditis.

Authors:  Emanuele Durante-Mangoni; Rosa Molaro; Domenico Iossa
Journal:  Curr Infect Dis Rep       Date:  2014-11       Impact factor: 3.725

Review 3.  Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections.

Authors:  Molly McAdow; Dominique M Missiakas; Olaf Schneewind
Journal:  J Innate Immun       Date:  2012-01-03       Impact factor: 7.349

Review 4.  Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity.

Authors:  Vigyasa Singh; Ujjal Jyoti Phukan
Journal:  Med Microbiol Immunol       Date:  2018-11-27       Impact factor: 3.402

Review 5.  Staphylococcus aureus Aggregation and Coagulation Mechanisms, and Their Function in Host-Pathogen Interactions.

Authors:  H A Crosby; J Kwiecinski; A R Horswill
Journal:  Adv Appl Microbiol       Date:  2016-08-04       Impact factor: 5.086

6.  The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.

Authors:  Thomas Vanassche; Marijke Peetermans; Lucas N L Van Aelst; Willy E Peetermans; Jan Verhaegen; Dominique M Missiakas; Olaf Schneewind; Marc F Hoylaerts; Peter Verhamme
Journal:  J Infect Dis       Date:  2013-03-26       Impact factor: 5.226

7.  Multimodal imaging of bacterial-host interface in mice and piglets with Staphylococcus aureus endocarditis.

Authors:  Peter Panizzi; Marvin Krohn-Grimberghe; Edmund Keliher; Yu-Xiang Ye; Jana Grune; Vanessa Frodermann; Yuan Sun; Charlotte G Muse; Kaitlyn Bushey; Yoshiko Iwamoto; Mandy M T van Leent; Anu Meerwaldt; Yohana C Toner; Jazz Munitz; Alexander Maier; Georgios Soultanidis; Claudia Calcagno; Carlos Pérez-Medina; Giuseppe Carlucci; Kay P Riddell; Sharron Barney; Glenn Horne; Brian Anderson; Ashoka Maddur-Appajaiah; Ingrid M Verhamme; Paul E Bock; Gregory R Wojtkiewicz; Gabriel Courties; Filip K Swirski; William R Church; Paul H Walz; D Michael Tillson; Willem J M Mulder; Matthias Nahrendorf
Journal:  Sci Transl Med       Date:  2020-11-04       Impact factor: 17.956

8.  Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood.

Authors:  Molly McAdow; Hwan Keun Kim; Andrea C Dedent; Antoni P A Hendrickx; Olaf Schneewind; Dominique M Missiakas
Journal:  PLoS Pathog       Date:  2011-10-20       Impact factor: 6.823

9.  Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model.

Authors:  Christoph Guggenberger; Christiane Wolz; Julie A Morrissey; Jürgen Heesemann
Journal:  PLoS Pathog       Date:  2012-01-12       Impact factor: 6.823

10.  The discovery of dabigatran etexilate.

Authors:  Joanne van Ryn; Ashley Goss; Norbert Hauel; Wolfgang Wienen; Henning Priepke; Herbert Nar; Andreas Clemens
Journal:  Front Pharmacol       Date:  2013-02-12       Impact factor: 5.810
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