Literature DB >> 20810773

Variability of the polymerase gene (NS5B) in hepatitis C virus-infected women.

Jason T Blackard1, Gang Ma, Berkeley N Limketkai, Jeffrey A Welge, Peter D Dryer, Christina M Martin, Yoichi Hiasa, Lynn E Taylor, Kenneth H Mayer, Denise J Jamieson, Kenneth E Sherman.   

Abstract

There are limited data on diversity within the hepatitis C virus polymerase (NS5B). In concordance with its key functional role during the life cycle, NS5B intrapatient variability was low. Moreover, differences between NS5B nonsynonymous (dN) and synonymous (dS) mutation rates (dN - dS) were positively correlated with CD4 cell count, while nonsynonymous mutations were strongly correlated with reduced replication in vivo.

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Year:  2010        PMID： 20810773      PMCID： PMC3020841          DOI： 10.1128/JCM.01613-10

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  21 in total

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Authors:  Norah J Shire; Paul S Horn; Susan D Rouster; Sandra Stanford; M Elaine Eyster; Kenneth E Sherman
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4.  Pegylated IFN-alpha2b plus ribavirin as therapy for chronic hepatitis C in HIV-infected patients.

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6.  Hepatitis C virus (HCV) diversity in HIV-HCV-coinfected subjects initiating highly active antiretroviral therapy.

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7.  HCV quasispecies evolution: association with progression to end-stage liver disease in hemophiliacs infected with HCV or HCV/HIV.

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8.  Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens.

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Review 9.  RNA-dependent RNA polymerase encoded by hepatitis C virus: biomedical applications.

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  5 in total

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2.  Analysis of a non-structural gene reveals evidence of possible hepatitis C virus (HCV) compartmentalization.

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3.  Naturally occurring mutations in the nonstructural region 5B of hepatitis C virus (HCV) from treatment-naïve Korean patients chronically infected with HCV genotype 1b.

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Journal:  PLoS One       Date:  2014-01-29       Impact factor: 3.240

Review 4.  Update on different aspects of HCV variability: focus on NS5B polymerase.

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Journal:  BMC Infect Dis       Date:  2014-09-05       Impact factor: 3.090

5.  Diversity of the hepatitis C virus NS5B gene during HIV co-infection.

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  5 in total

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