OBJECTIVE: the proinflammatory cytokine interleukin (IL)-6 has been linked with health morbidity, particularly risk for cardiovascular disease (CVD). The purpose of this study was to investigate the potential protective role of coping self-efficacy on the relationship between caregiving stress and circulating concentrations of IL-6. METHODS: a total of 62 elderly caregivers of patients with Alzheimer's disease (mean age: 74 years) were assessed for plasma concentrations of IL-6, caregiving-related overload, and coping self-efficacy. Multiple regression was used to examine the main effects of stress and self-efficacy, as well as the interaction between stress and self-efficacy, in predicting plasma IL-6 after controlling for age, gender, resting blood pressure, and obesity. RESULTS: there was a significant interaction between stress and self-efficacy in predicting IL-6. Post-hoc examination indicated that when self-efficacy was low, stress was significantly related to IL-6 (β = 0.43). However, when self-efficacy was high, stress was not significantly related to IL-6 (β = -0.10). CONCLUSION: caregiving stress in combination with low coping self-efficacy is significantly related to IL-6, a known risk marker for health morbidity, particularly CVD. However, stress was not associated with IL-6 with high self-efficacy. Although limited and preliminary, these results point to a potential protective effect of self-efficacy on caregiver health that can be tested in longitudinal studies. 2011 American Association for Geriatric Psychiatry.
OBJECTIVE: the proinflammatory cytokine interleukin (IL)-6 has been linked with health morbidity, particularly risk for cardiovascular disease (CVD). The purpose of this study was to investigate the potential protective role of coping self-efficacy on the relationship between caregiving stress and circulating concentrations of IL-6. METHODS: a total of 62 elderly caregivers of patients with Alzheimer's disease (mean age: 74 years) were assessed for plasma concentrations of IL-6, caregiving-related overload, and coping self-efficacy. Multiple regression was used to examine the main effects of stress and self-efficacy, as well as the interaction between stress and self-efficacy, in predicting plasma IL-6 after controlling for age, gender, resting blood pressure, and obesity. RESULTS: there was a significant interaction between stress and self-efficacy in predicting IL-6. Post-hoc examination indicated that when self-efficacy was low, stress was significantly related to IL-6 (β = 0.43). However, when self-efficacy was high, stress was not significantly related to IL-6 (β = -0.10). CONCLUSION: caregiving stress in combination with low coping self-efficacy is significantly related to IL-6, a known risk marker for health morbidity, particularly CVD. However, stress was not associated with IL-6 with high self-efficacy. Although limited and preliminary, these results point to a potential protective effect of self-efficacy on caregiver health that can be tested in longitudinal studies. 2011 American Association for Geriatric Psychiatry.
Authors: D G Baker; N N Ekhator; J W Kasckow; K K Hill; E Zoumakis; B A Dashevsky; G P Chrousos; T D Geracioti Journal: Neuroimmunomodulation Date: 2001 Impact factor: 2.492
Authors: L Ferrucci; T B Harris; J M Guralnik; R P Tracy; M C Corti; H J Cohen; B Penninx; M Pahor; R Wallace; R J Havlik Journal: J Am Geriatr Soc Date: 1999-06 Impact factor: 5.562
Authors: Alexandrea L Harmell; Elizabeth A Chattillion; Susan K Roepke; Brent T Mausbach Journal: Curr Psychiatry Rep Date: 2011-06 Impact factor: 5.285
Authors: Paula R Sherwood; Thomas J Price; Jason Weimer; Dianxu Ren; Heidi S Donovan; Charles W Given; Barbara A Given; Richard Schulz; Jennifer Prince; Catherine Bender; Florien W Boele; Anna L Marsland Journal: J Neurooncol Date: 2016-02-23 Impact factor: 4.130
Authors: Raeanne C Moore; Elizabeth A Chattillion; Jennifer Ceglowski; Jennifer Ho; Roland von Känel; Paul J Mills; Michael G Ziegler; Thomas L Patterson; Igor Grant; Brent T Mausbach Journal: Behav Res Ther Date: 2013-07-19