Literature DB >> 208080

Cell fusion induced by scrapie and Creutzfeldt-Jakob virus-infected brain preparations.

C Kidson, M C Moreau, D M Asher, P W Brown, H G Coon, D C Gajdusek, C J Gibbs.   

Abstract

Cell fusion was induced by brain extracts containing the scrapie virus and the virus of Creutzfeldt-Jakob disease. The assay involved quantitation of colony-forming ability in a double selection system, strandardized against fusion induced by Sendai virus. Correlation between the logarithm of virus dilution and the hybrid colony number gave similar curves for scrapie virus and Sendai virus. Fusion induction may explain some aspects of pathogenesis in these diseases and provide a potential in vitro assay.

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Year:  1978        PMID： 208080      PMCID： PMC392688          DOI： 10.1073/pnas.75.6.2969

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Amino acid metabolism in mammalian cell cultures.

Authors:  H EAGLE
Journal:  Science       Date:  1959-08-21       Impact factor: 47.728

2.  SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.

Authors:  J W LITTLEFIELD
Journal:  Science       Date:  1964-08-14       Impact factor: 47.728

3.  EFFECT OF HALOGENATED PYRIMIDINES AND THYMIDINE ON GROWTH OF L-CELLS AND A SUBLINE LACKING THYMIDINE KINASE.

Authors:  D R DUBBS; S KIT
Journal:  Exp Cell Res       Date:  1964-01       Impact factor: 3.905

4.  Pathology of Kuru.

Authors:  I KLATZO; D C GAJDUSEK; V ZIGAS
Journal:  Lab Invest       Date:  1959 Jul-Aug       Impact factor: 5.662

5.  Observations on kuru. III. Pathological features in five cases.

Authors:  M FOWLER; E G ROBERTSON
Journal:  Australas Ann Med       Date:  1959-02

6.  Experimental production of scrapie in goats.

Authors:  I H PATTISON; W S GORDON; G C MILLSON
Journal:  J Comp Pathol       Date:  1959-07       Impact factor: 1.311

7.  Elimination of nonspecific components from viral antigens by fluorocarbon.

Authors:  V V HAMPARIAN; F MULLER; K HUMMELER
Journal:  J Immunol       Date:  1958-06       Impact factor: 5.422

8.  Unconventional viruses and the origin and disappearance of kuru.

Authors:  D C Gajdusek
Journal:  Science       Date:  1977-09-02       Impact factor: 47.728

9.  Sedimentation properties of the scrapie agent.

Authors:  S B Prusiner; W J Hadlow; C M Eklund; R E Race
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

10.  Experimental kuru in the spider monkey. Histopathological and ultrastructural studies of the brain during early stages of incubation.

Authors:  E Beck; I J Bak; J F Christ; D C Gajdusek; C J Gibbs; R Hassler
Journal:  Brain       Date:  1975-12       Impact factor: 13.501
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  5 in total

1.  Role of VSV G antigen in the development of experimental spongiform encephalopathy in mice.

Authors:  O Robain; F Chany-Fournier; I Cerutti; M Màzlo; C Chany
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

2.  Neuroblastoma cell fusion by a temperature-sensitive mutant of vesicular stomatitis virus.

Authors:  J V Hughes; B J Dille; R L Thimmig; T C Johnson; S G Rabinowitz; M C Dal Canto
Journal:  J Virol       Date:  1979-06       Impact factor: 5.103

3.  Ultrastructural study of three cases of encephalopathy with hypsarrhythmia. Similarities of lesions with subacute spongiform encephalopathies.

Authors:  M Toga; D Gambarelli
Journal:  Acta Neuropathol       Date:  1982       Impact factor: 17.088

4.  Comparison of cell-fusing activity of brain suspensions from patients with Creutzfeldt-Jakob disease and other degenerative neurological diseases.

Authors:  M C Moreau-Dubois; P Brown; D C Gajdusek
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Experimental scrapie in golden Syrian hamsters: temporal comparison of in vitro cell-fusing activity with brain infectivity and histopathological changes.

Authors:  M C Moreau-Dubois; P Brown; R G Rohwer; C L Masters; M Franko; D C Gajdusek
Journal:  Infect Immun       Date:  1982-07       Impact factor: 3.441
  5 in total

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