Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.

Literature DB >> 20806907

Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.

Jingqiu Dai¹, Analia Sorribas, Wesley Y Yoshida, Michelle Kelly, Philip G Williams.

Abstract

Three isopropyl steroids, topsentinols K, L, and K trisulfate (1-3), were isolated from an undescribed species of Topsentia. The structures of the new compounds were determined by extensive 1D and 2D NMR experiments and mass spectrometry measurements. Topsentinol K trisulfate (3) inhibited the aspartic protease BACE1, although in a detergent-dependent manner suggestive of nonspecific aggregation.

Entities: Chemical Disease Gene Mutation

Mesh：

Substances：

Year: 2010 PMID： 20806907 PMCID： PMC4933315 DOI： 10.1021/np100374b

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

8 in total

1. Small-molecule aggregates inhibit amyloid polymerization.

Authors: Brian Y Feng; Brandon H Toyama; Holger Wille; David W Colby; Sean R Collins; Barnaby C H May; Stanley B Prusiner; Jonathan Weissman; Brian K Shoichet
Journal: Nat Chem Biol Date: 2008-01-27 Impact factor: 15.040

2. Neurosteroid pregnenolone sulfate inhibits stimulus-evoked EPSC via presynaptic inhibition of protein kinase A in rat prelimbic cortical neurons.

Authors: Jian-Li Sun; Yan-Lian Dong; Ying-Mei Fu; Yan-Hua Zhu; Yi Dong; Ping Zheng
Journal: Neuropharmacology Date: 2005-09 Impact factor: 5.250

3. New 24-isopropylcholesterol and 24-isopropenylcholesterol sulfate from the marine sponge Epipolasis species.

Authors: A Umeyama; K Adachi; S Ito; S Arihara
Journal: J Nat Prod Date: 2000-08 Impact factor: 4.050

4. Anthelmintic polyfunctional nitrogen-containing terpenoids from marine sponges.

Authors: K A Alvi; L Tenenbaum; P Crews
Journal: J Nat Prod Date: 1991 Jan-Feb Impact factor: 4.050

5. Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp.

Authors: Jessica A Digirolamo; Xing-Cong Li; Melissa R Jacob; Alice M Clark; Daneel Ferreira
Journal: J Nat Prod Date: 2009-08 Impact factor: 4.050

6. Ophirasterol, a new C31 sterol from the marine sponge Topsentia ophiraphidites.

Authors: Gladys J Calderón; Leonardo Castellanos; Carmenza Duque; Shizue Echigo; Noriyuki Hara; Yoshinori Fujimoto
Journal: Steroids Date: 2004-02 Impact factor: 2.668

7. Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Authors: Kristin E D Coan; David A Maltby; Alma L Burlingame; Brian K Shoichet
Journal: J Med Chem Date: 2009-04-09 Impact factor: 7.446

8. Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.

Authors: Emily L Whitson; Tim S Bugni; Priya S Chockalingam; Gisela P Concepcion; Mary Kay Harper; Min He; John N A Hooper; Gina C Mangalindan; Frank Ritacco; Chris M Ireland
Journal: J Nat Prod Date: 2008-06-18 Impact factor: 4.050

8 in total

5 in total

Topsentinols, 24-isopropyl steroids from the marine sponge Topsentia sp.

1. Small-molecule aggregates inhibit amyloid polymerization.

2. Neurosteroid pregnenolone sulfate inhibits stimulus-evoked EPSC via presynaptic inhibition of protein kinase A in rat prelimbic cortical neurons.

3. New 24-isopropylcholesterol and 24-isopropenylcholesterol sulfate from the marine sponge Epipolasis species.

4. Anthelmintic polyfunctional nitrogen-containing terpenoids from marine sponges.

5. Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp.

6. Ophirasterol, a new C31 sterol from the marine sponge Topsentia ophiraphidites.

7. Promiscuous aggregate-based inhibitors promote enzyme unfolding.

8. Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.

1. Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.

2. Bioactive marine drugs and marine biomaterials for brain diseases.

3. Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers.

4. New Halogenated Compounds from Halimeda macroloba Seaweed with Potential Inhibitory Activity against Malaria.

5. Topsensterols A-C, Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.