Literature DB >> 20806841

Pharmacotherapeutic approach to the treatment of addiction: persistent challenges.

Daniel S Zahm1.   

Abstract

The sequence of pathophysiological responses to repeated self-administration of addictive compounds is briefly described, as are prospects for development of drugs for addiction and some of those currently available. It is noted that the varying vulnerability of individuals to addictions creates ethical concerns regarding the application of drug abuse pharmacotherapies as they become more efficacious. It is noted further that relapse remains the most persistent challenge in the treatment of addictions.

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Year:  2010        PMID： 20806841      PMCID： PMC2964348     

Source DB:  PubMed          Journal:  Mo Med        ISSN： 0026-6620


  29 in total

1.  Neuroadaptation. Incubation of cocaine craving after withdrawal.

Authors:  J W Grimm; B T Hope; R A Wise; Y Shaham
Journal:  Nature       Date:  2001-07-12       Impact factor: 49.962

Review 2.  The reinstatement model of drug relapse: history, methodology and major findings.

Authors:  Yavin Shaham; Uri Shalev; Lin Lu; Harriet de Wit; Jane Stewart
Journal:  Psychopharmacology (Berl)       Date:  2002-10-26       Impact factor: 4.530

Review 3.  Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.

Authors:  P W Kalivas; J Stewart
Journal:  Brain Res Brain Res Rev       Date:  1991 Sep-Dec

4.  Classically conditioned responses in opioid and cocaine dependence: a role in relapse?

Authors:  A R Childress; A T McLellan; R Ehrman; C P O'Brien
Journal:  NIDA Res Monogr       Date:  1988

5.  Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

Authors:  G Di Chiara; A Imperato
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

Review 6.  The neural basis of drug craving: an incentive-sensitization theory of addiction.

Authors:  T E Robinson; K C Berridge
Journal:  Brain Res Brain Res Rev       Date:  1993 Sep-Dec

7.  Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects.

Authors:  N D Volkow; G J Wang; J S Fowler; J Logan; S J Gatley; R Hitzemann; A D Chen; S L Dewey; N Pappas
Journal:  Nature       Date:  1997-04-24       Impact factor: 49.962

8.  Relationship between subjective effects of cocaine and dopamine transporter occupancy.

Authors:  N D Volkow; G J Wang; M W Fischman; R W Foltin; J S Fowler; N N Abumrad; S Vitkun; J Logan; S J Gatley; N Pappas; R Hitzemann; C E Shea
Journal:  Nature       Date:  1997-04-24       Impact factor: 49.962

9.  Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: reversal by D(1) antagonists.

Authors:  R Ciccocioppo; P P Sanna; F Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

10.  Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine.

Authors:  L H Parsons; A D Smith; J B Justice
Journal:  Synapse       Date:  1991-09       Impact factor: 2.562
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  2 in total

Review 1.  Glutamatergic medications for the treatment of drug and behavioral addictions.

Authors:  M Foster Olive; Richard M Cleva; Peter W Kalivas; Robert J Malcolm
Journal:  Pharmacol Biochem Behav       Date:  2011-04-22       Impact factor: 3.533

Review 2.  An update on the connections of the ventral mesencephalic dopaminergic complex.

Authors:  L Yetnikoff; H N Lavezzi; R A Reichard; D S Zahm
Journal:  Neuroscience       Date:  2014-04-13       Impact factor: 3.590
  2 in total

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