| Literature DB >> 20805013 |
Subheet Jain1, Amanpreet Kaur, Richa Puri, Puneet Utreja, Anubhuti Jain, Mahesh Bhide, Rakesh Ratnam, Vinay Singh, A S Patil, N Jayaraman, Gaurav Kaushik, Subodh Yadav, K L Khanduja.
Abstract
In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen. Drug-dendrimer complex was prepared and characterized by FTIR, solubility and in vitro drug release study. PETIM dendrimer was found to have significantly less toxicity in A541 cells compared to Poly amido amine (PAMAM) dendrimer. Further, acute and 28 days sub-acute toxicity measurement in mice showed no mortality, hematological, biochemical or histopathological changes up to 80 mg/kg dose of PETIM dendrimer. The results of study demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.Entities:
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Year: 2010 PMID： 20805013 DOI： 10.1016/j.ejmech.2010.08.006
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514