| Literature DB >> 20805006 |
Yuta Yamamoto1, Toshihito Tanahashi, Sakurako Katsuura, Ken Kurokawa, Kensei Nishida, Yuki Kuwano, Tomoko Kawai, Shigetada Teshima-Kondo, Sachiko Chikahisa, Yoshihiro Tsuruo, Hiroyoshi Sei, Kazuhito Rokutan.
Abstract
In this study, we examined the effects of IL-18 deficiency on behaviors and gene expression profiles in 6 brain regions. IL-18(-/-) mice reduced depressive-like behavior and changed gene expressions predominantly in the amygdala compared with wild-type mice. Pathway analysis of the differentially expressed genes ranked behavior as the top-scored biological function. Of note, the absence of IL-18 decreased Avp, Hcrt, Oxt, and Pmch mRNA levels and the number of arginine vasopressin- and oxytocin-positive cells in the amygdala, but not in the hypothalamus. Our results suggest that IL-18-dependent vasopressinergic and oxytocinergic circuitry in the amygdala may regulate depressive-like behaviors in mice.Entities:
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Year: 2010 PMID： 20805006 DOI： 10.1016/j.jneuroim.2010.07.024
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478