Literature DB >> 20804753

Activation of human monocytes by a formyl peptide receptor 2-derived pepducin.

Ha Young Lee1, Sang Doo Kim, Jae Woong Shim, Hak Jung Kim, Jae Young Kwon, Jong-Min Kim, Suk-Hwan Baek, Joon Seong Park, Yoe-Sik Bae.   

Abstract

We synthesized and investigated the effect of formyl peptide receptor 2 (FPR2)-derived pepducins in human monocytes. The FPR2-based cell-penetrating lipopeptide, "pepducin" (F2pal-16), stimulated intracellular calcium increase in human monocytes via pertussis toxin (PTX)-sensitive G-protein and phospholipase C (PLC) activity. From a functional aspect, we showed that F2pal-16 stimulated monocyte chemotaxis. F2pal-16 also stimulated the generation of superoxide anion in human monocytes. Moreover, F2pal-16 dramatically increased the production of several kinds of pro-inflammatory cytokines (CXCL8, CCL2, IL-1β and TNF-α) in human monocytes via NF-κB activation. Since FPR2 plays an important role in immune responses, F2pal-16 can serve as a useful reagent for the study of FPR2-mediated immune modulation.
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20804753     DOI： 10.1016/j.febslet.2010.08.036

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Development and characterization of pepducins as Gs-biased allosteric agonists.

Authors:  Richard Carr; Yang Du; Julie Quoyer; Reynold A Panettieri; Jay M Janz; Michel Bouvier; Brian K Kobilka; Jeffrey L Benovic
Journal:  J Biol Chem       Date:  2014-11-13       Impact factor: 5.157

2.  Human Neuropeptide S Receptor Is Activated via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues.

Authors:  Yuan Liao; Bin Lu; Qiang Ma; Gang Wu; Xiangru Lai; Jiashu Zang; Ying Shi; Dongxiang Liu; Feng Han; Naiming Zhou
Journal:  J Biol Chem       Date:  2016-02-10       Impact factor: 5.157

Review 3.  Turning receptors on and off with intracellular pepducins: new insights into G-protein-coupled receptor drug development.

Authors:  Katie O'Callaghan; Athan Kuliopulos; Lidija Covic
Journal:  J Biol Chem       Date:  2012-02-28       Impact factor: 5.157

Review 4.  Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions.

Authors:  Claes Dahlgren; André Holdfeldt; Simon Lind; Jonas Mårtensson; Michael Gabl; Lena Björkman; Martina Sundqvist; Huamei Forsman
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-11

5.  Pepducins and Other Lipidated Peptides as Mechanistic Probes and Therapeutics.

Authors:  Ping Zhang; Lidija Covic; Athan Kuliopulos
Journal:  Methods Mol Biol       Date:  2015

Review 6.  Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives.

Authors:  Igor A Schepetkin; Andrei I Khlebnikov; Liliya N Kirpotina; Mark T Quinn
Journal:  Int Immunopharmacol       Date:  2015-09-15       Impact factor: 4.932

7.  Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.

Authors:  Julie Quoyer; Jay M Janz; Jiansong Luo; Yong Ren; Sylvain Armando; Viktoria Lukashova; Jeffrey L Benovic; Kenneth E Carlson; Stephen W Hunt; Michel Bouvier
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-05       Impact factor: 11.205

Review 8.  Formyl-Peptide Receptor Agonists and Amorphous SiO2-NPs Synergistically and Selectively Increase the Inflammatory Responses of Human Monocytes and PMNs.

Authors:  Regina Tavano; Daniela Segat; Chiara Fedeli; Giulia Malachin; Elisa Lubian; Fabrizio Mancin; Emanuele Papini
Journal:  Nanobiomedicine (Rij)       Date:  2016-01-01

9.  A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.

Authors:  Michael Gabl; Malene Winther; Sarah Line Skovbakke; Johan Bylund; Claes Dahlgren; Huamei Forsman
Journal:  PLoS One       Date:  2014-10-10       Impact factor: 3.240

10.  Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing.

Authors:  Vasundhara Kain; Fei Liu; Veronika Kozlovskaya; Kevin A Ingle; Subhashini Bolisetty; Anupam Agarwal; Santosh Khedkar; Sumanth D Prabhu; Eugenia Kharlampieva; Ganesh V Halade
Journal:  Sci Rep       Date:  2017-08-30       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.