Literature DB >> 20804056

[Tumor-specific expression of PBOV1, a new gene in evolution].

L L Krukovskaia, N D Samusik, E S Shilov, D E Polev, A P Kozlov.   

Abstract

We identified mRNA of the newly discovered gene PBOV1 in a multitude of samples from tumors of the brain, lung, liver, gallbladder, colon, small intestine, mammary gland, uterus, ovary, ureter, adrenals, parotid, thymus and spleen. However, out of 29 intact adult and 8 fetal tissues, only pancreas was characterized by weak expression of the gene. Our results demonstrated that the PBOV1 gene expression is tumor-specific and has a potential as tumor marker. It is worth mentioning that we had predicted that property on the basis of available evolutionary data.

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Year:  2010        PMID: 20804056

Source DB:  PubMed          Journal:  Vopr Onkol        ISSN: 0507-3758


  4 in total

1.  Association between the overexpression of PBOV1 and the prognosis of patients with hepatocellular carcinoma.

Authors:  Chengbiao Xue; Zibiao Zhong; Shaojun Ye; Yanfeng Wang; Qifa Ye
Journal:  Oncol Lett       Date:  2018-06-25       Impact factor: 2.967

2.  MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms' Tumor Cell by Targeting PBOV1.

Authors:  Zheng-Tuan Guo; Qiang Yu; Chunlin Miao; Wenan Ge; Peng Li
Journal:  Mol Cell Biol       Date:  2022-07-11       Impact factor: 5.069

3.  PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer.

Authors:  Nikolay Samusik; Larisa Krukovskaya; Irina Meln; Evgeny Shilov; Andrey P Kozlov
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

Review 4.  Expression of evolutionarily novel genes in tumors.

Authors:  A P Kozlov
Journal:  Infect Agent Cancer       Date:  2016-07-19       Impact factor: 2.965

  4 in total

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