Literature DB >> 20803588

A concise total synthesis of amphidinolide T2.

Huoming Li1, Jinlong Wu, Jialu Luo, Wei-Min Dai.   

Abstract

RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2010        PMID： 20803588     DOI： 10.1002/chem.201001794

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  8 in total

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Review 8.  Marine-Derived Macrolides 1990-2020: An Overview of Chemical and Biological Diversity.

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  8 in total

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