BACKGROUND: The aim of the study was to assess diurnal melatonin secretion in children with refractory epilepsy (N=74) as compared to children without epileptic seizures (N=37) and to compare melatonin secretion in children with focal and generalized refractory epilepsy. MATERIAL/ METHODS: In the study group 4 subgroups were defined: children with focal symptomatic epilepsy, focal cryptogenic epilepsy, generalized symptomatic epilepsy, and generalized cryptogenic epilepsy. Melatonin level was measured every 3 hours using the RIA method. RESULTS: Analysis of diurnal melatonin secretion indicated a lower level of the hormone in patients with refractory epilepsy. The daily rhythm of melatonin secretion in the study group was maintained, with a peak shift of melatonin secretion especially visible in the subgroup with generalized symptomatic refractory epilepsy in the age group between 6 months and 3 years of age. CONCLUSIONS: The hypothesis may be formed that a lowered level of melatonin in the study group in relation to the comparison group is the consequence of the natural course of epilepsy or is influenced by antiepileptic drugs.
BACKGROUND: The aim of the study was to assess diurnal melatonin secretion in children with refractory epilepsy (N=74) as compared to children without epilepticseizures (N=37) and to compare melatonin secretion in children with focal and generalized refractory epilepsy. MATERIAL/ METHODS: In the study group 4 subgroups were defined: children with focal symptomatic epilepsy, focal cryptogenic epilepsy, generalized symptomatic epilepsy, and generalized cryptogenic epilepsy. Melatonin level was measured every 3 hours using the RIA method. RESULTS: Analysis of diurnal melatonin secretion indicated a lower level of the hormone in patients with refractory epilepsy. The daily rhythm of melatonin secretion in the study group was maintained, with a peak shift of melatonin secretion especially visible in the subgroup with generalized symptomatic refractory epilepsy in the age group between 6 months and 3 years of age. CONCLUSIONS: The hypothesis may be formed that a lowered level of melatonin in the study group in relation to the comparison group is the consequence of the natural course of epilepsy or is influenced by antiepileptic drugs.
Authors: Sejal V Jain; Paul S Horn; Narong Simakajornboon; Dean W Beebe; Katherine Holland; Anna W Byars; Tracy A Glauser Journal: Sleep Med Date: 2015-01-21 Impact factor: 3.492
Authors: Ewa Pronicka; Anna Weglewska-Jurkiewicz; Maciej Pronicki; Jolanta Sykut-Cegielska; Pawel Kowalski; Magdalena Pajdowska; Irena Jankowska; Katarzyna Kotulska; Piotr Kalicinski; Joanna Jakobkiewicz-Banecka; Grzegorz Wegrzyn Journal: Med Sci Monit Date: 2011-04
Authors: Carolyn Bridgemohan; David M Cochran; Yamini J Howe; Katherine Pawlowski; Andrew W Zimmerman; George M Anderson; Roula Choueiri; Laura Sices; Karen J Miller; Monica Ultmann; Jessica Helt; Peter W Forbes; Laura Farfel; Stephanie J Brewster; Jean A Frazier; Ann M Neumeyer Journal: Front Integr Neurosci Date: 2019-08-02
Authors: Justyna Paprocka; Marek Kijonka; Piotr Wojcieszek; Marcin Pęcka; Ewa Emich-Widera; Maria Sokół Journal: Int J Endocrinol Date: 2017-12-12 Impact factor: 3.257