OBJECTIVE: To characterize the clinical presentation, course and mortality of pandemic influenza in HIV-1-infected patients in Santiago, Chile. METHODS: Prospective observational study. RESULTS: Thirty patients were included (three hospitalized), 93% were on HAART, mean CD4(+) cell count was 423 cells/μl and viral load was undetectable in 77% of patients. All patients had fever, 90% had cough, 80% had myalgias, 70% had pharyngeal congestion, 47% had coryza, 47% had odynophagia, 37% had headache and 23% had vomiting. Four patients developed pneumonia. All patients received antiviral therapy and no patient died. CONCLUSIONS: HIV patients infected by the new influenza A pandemic (H1N1) virus behave similarly to the general population.
OBJECTIVE: To characterize the clinical presentation, course and mortality of pandemic influenza in HIV-1-infectedpatients in Santiago, Chile. METHODS: Prospective observational study. RESULTS: Thirty patients were included (three hospitalized), 93% were on HAART, mean CD4(+) cell count was 423 cells/μl and viral load was undetectable in 77% of patients. All patients had fever, 90% had cough, 80% had myalgias, 70% had pharyngeal congestion, 47% had coryza, 47% had odynophagia, 37% had headache and 23% had vomiting. Four patients developed pneumonia. All patients received antiviral therapy and no patient died. CONCLUSIONS: HIV patients infected by the new influenza A pandemic (H1N1) virus behave similarly to the general population.
Authors: Hana M El Sahly; Charles Davis; Karen Kotloff; Jeffery Meier; Patricia L Winokur; Anna Wald; Christine Johnston; Sarah L George; Rebecca C Brady; Corinne Lehmann; Abbie Stokes-Riner; Wendy A Keitel Journal: J Infect Dis Date: 2012-01-24 Impact factor: 5.226
Authors: Sinthujan Jegaskanda; Jeanette C Reece; Robert De Rose; John Stambas; Lucy Sullivan; Andrew G Brooks; Stephen J Kent; Amy Sexton Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240
Authors: Claire-Anne Siegrist; Christian van Delden; Michael Bel; Christophe Combescure; Cécile Delhumeau; Matthias Cavassini; Olivier Clerc; Sara Meier; Karine Hadaya; Paola M Soccal; Sabine Yerly; Laurent Kaiser; Bernard Hirschel; Alexandra Calmy Journal: PLoS One Date: 2012-07-27 Impact factor: 3.240