Literature DB >> 20802083

Engineered lactic acid bacterium Lactococcus lactis capable of binding antibodies and tumor necrosis factor alpha.

Matjaz Ravnikar1, Borut Strukelj, Natasa Obermajer, Mojca Lunder, Ales Berlec.   

Abstract

We have optimized the display of the B domain of staphylococcal protein A on the surface of Lactococcus lactis. The maximum binding capacity was estimated at 0.146 μg of antibody per 10⁸ cells and was sustained at 86% after treatment with simulated gastric juice. A tumor necrosis factor alpha (TNF-α)-binding affibody was also displayed and bound TNF-α, which could be useful in the treatment of inflammatory bowel disease.

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Year:  2010        PMID： 20802083      PMCID： PMC2953040          DOI： 10.1128/AEM.00190-10

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  26 in total

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Authors:  D G de Silva; L N Mendis; N Sheron; G J Alexander; D C Candy; H Chart; B Rowe
Journal:  Lancet       Date:  1992-08-08       Impact factor: 79.321

2.  A synthetic IgG-binding domain based on staphylococcal protein A.

Authors:  B Nilsson; T Moks; B Jansson; L Abrahmsén; A Elmblad; E Holmgren; C Henrichson; T A Jones; M Uhlén
Journal:  Protein Eng       Date:  1987 Feb-Mar

3.  Staphylococcal protein A consists of five IgG-binding domains.

Authors:  T Moks; L Abrahmsén; B Nilsson; U Hellman; J Sjöquist; M Uhlén
Journal:  Eur J Biochem       Date:  1986-05-02

4.  Controlled production of stable heterologous proteins in Lactococcus lactis.

Authors:  A Miyoshi; I Poquet; V Azevedo; J Commissaire; L Bermudez-Humaran; E Domakova; Y Le Loir; S C Oliveira; A Gruss; P Langella
Journal:  Appl Environ Microbiol       Date:  2002-06       Impact factor: 4.792

5.  Oral administration of avian tumor necrosis factor antibodies effectively treats experimental colitis in rats.

Authors:  K L Worledge; R Godiska; T A Barrett; J A Kink
Journal:  Dig Dis Sci       Date:  2000-12       Impact factor: 3.199

6.  Signal peptide and propeptide optimization for heterologous protein secretion in Lactococcus lactis.

Authors:  Y Le Loir; S Nouaille; J Commissaire; L Brétigny; A Gruss; P Langella
Journal:  Appl Environ Microbiol       Date:  2001-09       Impact factor: 4.792

7.  Development of novel whole-cell immunoadsorbents by yeast surface display of the IgG-binding domain.

Authors:  Y Nakamura; S Shibasaki; M Ueda; A Tanaka; H Fukuda; A Kondo
Journal:  Appl Microbiol Biotechnol       Date:  2001-11       Impact factor: 4.813

8.  Functional analysis of the Lactococcus lactis usp45 secretion signal in the secretion of a homologous proteinase and a heterologous alpha-amylase.

Authors:  M van Asseldonk; W M de Vos; G Simons
Journal:  Mol Gen Genet       Date:  1993-09

9.  In situ delivery of passive immunity by lactobacilli producing single-chain antibodies.

Authors:  Carina Krüger; Yanzhong Hu; Qiang Pan; Harold Marcotte; Anna Hultberg; Dipu Delwar; Philip J van Dalen; Peter H Pouwels; Rob J Leer; Charles G Kelly; Craig van Dollenweerd; Julian K Ma; Lennart Hammarström
Journal:  Nat Biotechnol       Date:  2002-07       Impact factor: 54.908

10.  Generation of tumour-necrosis-factor-alpha-specific affibody molecules capable of blocking receptor binding in vitro.

Authors:  Andreas Jonsson; Helena Wållberg; Nina Herne; Stefan Ståhl; Fredrik Y Frejd
Journal:  Biotechnol Appl Biochem       Date:  2009-08-17       Impact factor: 2.431
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  13 in total

1.  Identification of candidate carrier proteins for surface display on Lactococcus lactis by theoretical and experimental analyses of the surface proteome.

Authors:  Aleš Berlec; Petra Zadravec; Zala Jevnikar; Borut Štrukelj
Journal:  Appl Environ Microbiol       Date:  2010-12-23       Impact factor: 4.792

2.  Improvement of LysM-mediated surface display of designed ankyrin repeat proteins (DARPins) in recombinant and nonrecombinant strains of Lactococcus lactis and Lactobacillus Species.

Authors:  Petra Zadravec; Borut Štrukelj; Aleš Berlec
Journal:  Appl Environ Microbiol       Date:  2015-01-09       Impact factor: 4.792

3.  Lectin-Mediated Binding of Engineered Lactococcus lactis to Cancer Cells.

Authors:  Tina Vida Plavec; Abida Zahirović; Petra Zadravec; Jerica Sabotič; Aleš Berlec
Journal:  Microorganisms       Date:  2021-01-22

Review 4.  Exploiting the peptidoglycan-binding motif, LysM, for medical and industrial applications.

Authors:  Ganesh Ram R Visweswaran; Kees Leenhouts; Maarten van Roosmalen; Jan Kok; Girbe Buist
Journal:  Appl Microbiol Biotechnol       Date:  2014-03-21       Impact factor: 4.813

5.  A New Broad Range Plasmid for DNA Delivery in Eukaryotic Cells Using Lactic Acid Bacteria: In Vitro and In Vivo Assays.

Authors:  Pamela Mancha-Agresti; Mariana Martins Drumond; Fillipe Luiz Rosa do Carmo; Monica Morais Santos; Janete Soares Coelho Dos Santos; Franco Venanzi; Jean-Marc Chatel; Sophie Yvette Leclercq; Vasco Azevedo
Journal:  Mol Ther Methods Clin Dev       Date:  2016-12-24       Impact factor: 6.698

6.  Evasin-displaying lactic acid bacteria bind different chemokines and neutralize CXCL8 production in Caco-2 cells.

Authors:  Katja Škrlec; Anja Pucer Janež; Boris Rogelj; Borut Štrukelj; Aleš Berlec
Journal:  Microb Biotechnol       Date:  2017-07-24       Impact factor: 5.813

7.  In vivo imaging of Lactococcus lactis, Lactobacillus plantarum and Escherichia coli expressing infrared fluorescent protein in mice.

Authors:  Aleš Berlec; Janja Završnik; Miha Butinar; Boris Turk; Borut Štrukelj
Journal:  Microb Cell Fact       Date:  2015-11-14       Impact factor: 5.328

Review 8.  Display of recombinant proteins at the surface of lactic acid bacteria: strategies and applications.

Authors:  C Michon; P Langella; V G H Eijsink; G Mathiesen; J M Chatel
Journal:  Microb Cell Fact       Date:  2016-05-03       Impact factor: 5.328

9.  Development of Recombinant Lactococcus lactis Displaying Albumin-Binding Domain Variants against Shiga Toxin 1 B Subunit.

Authors:  Petra Zadravec; Lucie Marečková; Hana Petroková; Vesna Hodnik; Milica Perišić Nanut; Gregor Anderluh; Borut Štrukelj; Petr Malý; Aleš Berlec
Journal:  PLoS One       Date:  2016-09-08       Impact factor: 3.240

10.  p19-Targeting ILP Protein Blockers of IL-23/Th-17 Pro-Inflammatory Axis Displayed on Engineered Bacteria of Food Origin.

Authors:  Katja Škrlec; Petra Zadravec; Marie Hlavničková; Milan Kuchař; Lucie Vaňková; Hana Petroková; Lucie Křížová; Jiří Černý; Aleš Berlec; Petr Malý
Journal:  Int J Mol Sci       Date:  2018-07-01       Impact factor: 5.923
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