| Literature DB >> 20800318 |
Julie K Iwasaki1, Divya Srivastava, Ronald L Moy, Henry J Lin, David J Kouba.
Abstract
Mutations in the sonic hedgehog signaling pathway play a key role in the development of basal cell carcinomas. Specifically, mutations in the PTCH1 (also known as PTCH or PTC1) and SMO genes cause tumor formation through constitutive activation of the pathway. Misregulation of the pathway has also been implicated in the nevoid basal cell carcinoma syndrome and other tumors. Understanding the function of the sonic hedgehog pathway has led to novel strategies for treatment. In this review we highlight the role of the pathway in the pathogenesis of basal cell carcinoma and review potential targeted therapies.Entities:
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Year: 2010 PMID： 20800318 DOI： 10.1016/j.jaad.2010.06.054
Source DB: PubMed Journal: J Am Acad Dermatol ISSN： 0190-9622 Impact factor: 11.527