Daptomycin as successful treatment for a refractory case of prosthetic valve endocarditis because of methicillin-sensitive Staphylococcus aureus.

We report on an intravenous drug user who presented with methicillin-sensitive Staphylococcus aureus bacteremia and endocarditis of a prosthetic tricuspid valve, with a 4-cm vegetation refractory to standard antibiotic treatment. The patient responded to intravenous daptomycin therapy clinically and microbiologically, despite an absence of surgical intervention.