Literature DB >> 20798904

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe.

Lei Cui1, Ye Zhong, Weiping Zhu, Yufang Xu, Xuhong Qian.   

Abstract

A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

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Year:  2010        PMID： 20798904     DOI： 10.1039/c0cc01000f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

Review 1.  Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives.

Authors:  Qiang Jin; JingJing Wu; Yue Wu; Hongxin Li; Moshe Finel; Dandan Wang; Guangbo Ge
Journal:  Acta Pharm Sin B       Date:  2022-01-21       Impact factor: 14.903

2.  HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages.

Authors:  Charlotte V Hobbs; Tatiana Voza; Patricia De La Vega; Jillian Vanvliet; Solomon Conteh; Scott R Penzak; Michael P Fay; Nicole Anders; Tiina Ilmet; Yonghua Li; William Borkowsky; Urszula Krzych; Patrick E Duffy; Photini Sinnis
Journal:  J Infect Dis       Date:  2012-12-01       Impact factor: 5.226

3.  A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a case study.

Authors:  Zi-Ru Dai; Lei Feng; Qiang Jin; Hailing Cheng; Yan Li; Jing Ning; Yang Yu; Guang-Bo Ge; Jing-Nan Cui; Ling Yang
Journal:  Chem Sci       Date:  2016-12-19       Impact factor: 9.825

4.  A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease.

Authors:  Yuehua Chen; Yuzhu Wang; Yonggang Yang; Yuhuan Li; Yafu Wang; Ge Wang; Tony D James; Xiaopeng Xuan; Hua Zhang; Yufang Liu
Journal:  Chem Sci       Date:  2020-05-25       Impact factor: 9.825
  4 in total

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