OBJECTIVE: Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia. METHODS: We performed an updated meta-analysis focusing on high-exposure groups and myeloid leukemia and included two large recent studies: one involving >25,000 workers in US formaldehyde industries and the other involving a cohort of >13,000 funeral directors and embalmers. RESULTS: Formaldehyde was associated with increased risks of leukemia (relative risk = 1.53; 95% confidence interval = 1.11 to 2.21; P = 0.005; 14 studies), specifically myeloid leukemia (relative risk = 2.47; 95% confidence interval = 1.42 to 4.27; P = 0.001; 4 studies). CONCLUSION: These findings provide evidence of increased myeloid leukemia risk with exposure to formaldehyde.
OBJECTIVE:Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia. METHODS: We performed an updated meta-analysis focusing on high-exposure groups and myeloid leukemia and included two large recent studies: one involving >25,000 workers in US formaldehyde industries and the other involving a cohort of >13,000 funeral directors and embalmers. RESULTS:Formaldehyde was associated with increased risks of leukemia (relative risk = 1.53; 95% confidence interval = 1.11 to 2.21; P = 0.005; 14 studies), specifically myeloid leukemia (relative risk = 2.47; 95% confidence interval = 1.42 to 4.27; P = 0.001; 4 studies). CONCLUSION: These findings provide evidence of increased myeloid leukemia risk with exposure to formaldehyde.
Authors: Lorenz R Rhomberg; Lisa A Bailey; Julie E Goodman; Ali K Hamade; David Mayfield Journal: Crit Rev Toxicol Date: 2011-06-02 Impact factor: 5.635
Authors: Bryan A Bassig; Luoping Zhang; Roel Vermeulen; Xiaojiang Tang; Guilan Li; Wei Hu; Weihong Guo; Mark P Purdue; Songnian Yin; Stephen M Rappaport; Min Shen; Zhiying Ji; Chuangyi Qiu; Yichen Ge; H Dean Hosgood; Boris Reiss; Banghua Wu; Yuxuan Xie; Laiyu Li; Fei Yue; Laura E Beane Freeman; Aaron Blair; Richard B Hayes; Hanlin Huang; Martyn T Smith; Nathaniel Rothman; Qing Lan Journal: Carcinogenesis Date: 2016-05-02 Impact factor: 4.944