Literature DB >> 20797711

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats.

Letteria Minutoli1, Salvatore Arena, Giulio Bonvissuto, Alessandra Bitto, Francesca Polito, Natasha Irrera, Francesco Arena, Eugenia Fragalà, Carmelo Romeo, Piero Antonio Nicotina, Carmine Fazzari, Herbert Marini, Alessandra Implatini, Silvia Grimaldi, Noemi Cantone, Vincenzo Di Benedetto, Francesco Squadrito, Domenica Altavilla, Giuseppe Morgia.   

Abstract

In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20797711     DOI： 10.1016/j.fertnstert.2010.07.1047

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  14 in total

1.  Medical perspective in testicular ischemia-reperfusion injury.

Authors:  Salvatore Arena; Roberta Iacona; Pietro Antonuccio; Tiziana Russo; Vincenzo Salvo; Eloisa Gitto; Pietro Impellizzeri; Carmelo Romeo
Journal:  Exp Ther Med       Date:  2017-03-30       Impact factor: 2.447

2.  Preparation of a novel composite nanofiber gel-encapsulated human placental extract through layer-by-layer self-assembly.

Authors:  Guohui Liu; X I Chen; W U Zhou; Shuhua Yang; Shunan Ye; Faqi Cao; Y I Liu; Yuan Xiong
Journal:  Exp Ther Med       Date:  2016-02-17       Impact factor: 2.447

3.  Polydeoxyribonucleotide, an Adenosine-A2A Receptor Agonist, Preserves Blood Testis Barrier from Cadmium-Induced Injury.

Authors:  Francesco Squadrito; Antonio Micali; Mariagrazia Rinaldi; Natasha Irrera; Herbert Marini; Domenico Puzzolo; Antonina Pisani; Cesare Lorenzini; Andrea Valenti; Rosaria Laurà; Antonino Germanà; Alessandra Bitto; Gabriele Pizzino; Giovanni Pallio; Domenica Altavilla; Letteria Minutoli
Journal:  Front Pharmacol       Date:  2017-01-10       Impact factor: 5.810

4.  Polydeoxyribonucleotide Ameliorates Lipopolysaccharide-Induced Lung Injury by Inhibiting Apoptotic Cell Death in Rats.

Authors:  Jin An; So Hee Park; Il-Gyu Ko; Jun-Jang Jin; Lakkyong Hwang; Eun-Sang Ji; Sang-Hoon Kim; Chang-Ju Kim; So Young Park; Jae-Joon Hwang; Cheon Woong Choi
Journal:  Int J Mol Sci       Date:  2017-08-24       Impact factor: 5.923

Review 5.  Pharmacological Activity and Clinical Use of PDRN.

Authors:  Francesco Squadrito; Alessandra Bitto; Natasha Irrera; Gabriele Pizzino; Giovanni Pallio; Letteria Minutoli; Domenica Altavilla
Journal:  Front Pharmacol       Date:  2017-04-26       Impact factor: 5.810

Review 6.  Complex regional pain syndrome: a recent update.

Authors:  En Lin Goh; Swathikan Chidambaram; Daqing Ma
Journal:  Burns Trauma       Date:  2017-01-19

7.  Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.

Authors:  Letteria Minutoli; Salvatore Arena; Pietro Antonuccio; Carmelo Romeo; Alessandra Bitto; Carlo Magno; Mariagrazia Rinaldi; Antonio Micali; Natasha Irrera; Gabriele Pizzino; Federica Galfo; Francesco Squadrito; Domenica Altavilla; Herbert Marini
Journal:  Biomed Res Int       Date:  2015-08-04       Impact factor: 3.411

8.  Treatment for Acute Stage Complex Regional Pain Syndrome Type II with Polydeoxyribonucleotide Injection.

Authors:  Kun Soo Jang; Hyeun Sung Kim
Journal:  J Korean Neurosurg Soc       Date:  2016-09-08

9.  Nutraceutical Effects of Lycopene in Experimental Varicocele: An "In Vivo" Model to Study Male Infertility.

Authors:  Pietro Antonuccio; Antonio Micali; Domenico Puzzolo; Carmelo Romeo; Giovanna Vermiglio; Violetta Squadrito; Jose Freni; Giovanni Pallio; Vincenzo Trichilo; Maria Righi; Natasha Irrera; Domenica Altavilla; Francesco Squadrito; Herbert R Marini; Letteria Minutoli
Journal:  Nutrients       Date:  2020-05-25       Impact factor: 5.717

10.  Neuroprotective Effects of Polydeoxyribonucleotide in a Murine Model of Cadmium Toxicity.

Authors:  Herbert R Marini; Domenico Puzzolo; Antonio Micali; Elena Bianca Adamo; Natasha Irrera; Antonina Pisani; Giovanni Pallio; Vincenzo Trichilo; Consuelo Malta; Alessandra Bitto; Francesco Squadrito; Domenica Altavilla; Letteria Minutoli
Journal:  Oxid Med Cell Longev       Date:  2018-08-29       Impact factor: 6.543
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