BACKGROUND: Lung cancer has become one of the most dangerous malignant tumor in the world nowadays, whose pathogenesis is complex involving multi-genes and multi-elements. In this study, we try to explore the values of serum SYK and vascular endothelial growth factor-C (VEGF-C) in lymph node metastasis of lung adenocarcinoma. METHODS: Serum SYK and VEGF were examined in 160 lung adenocarcinoma patients with various metastasis lesions and 40 healthy volunteers by ELISA. RESULTS: The serum SYK level of the lung adenocarcinoma patients were remarkably lower than those of normal persons (P <0.05); The SYK level decreased while the lymph nodes area increased along with their metastasis (P <0.05), and the serum VEGF-C level were remarkably higher than those of healthy objects (P <0.05). The VEGF-C level increased with the increase of lymph nodes metastasis (P <0.05). For the serum level of SYK and VEGF-C, there was no statistical difference in sex and age (P <0.05). Negative correlation was found between SYK and VEGF-C (r =0.650, P <0.05). CONCLUSIONS: The serum level of SYK and VEGF-C are closely related to the lymph nodes metastasis of lung adenocarcinoma. Combination detection of SYK and VEGF-C might be helpful for the predict of lymph nodes metastasis of lung adenocarcinoma.
BACKGROUND: Lung cancer has become one of the most dangerous malignant tumor in the world nowadays, whose pathogenesis is complex involving multi-genes and multi-elements. In this study, we try to explore the values of serum SYK and vascular endothelial growth factor-C (VEGF-C) in lymph node metastasis of lung adenocarcinoma. METHODS: Serum SYK and VEGF were examined in 160 lung adenocarcinomapatients with various metastasis lesions and 40 healthy volunteers by ELISA. RESULTS: The serum SYK level of the lung adenocarcinomapatients were remarkably lower than those of normal persons (P <0.05); The SYK level decreased while the lymph nodes area increased along with their metastasis (P <0.05), and the serum VEGF-C level were remarkably higher than those of healthy objects (P <0.05). The VEGF-C level increased with the increase of lymph nodes metastasis (P <0.05). For the serum level of SYK and VEGF-C, there was no statistical difference in sex and age (P <0.05). Negative correlation was found between SYK and VEGF-C (r =0.650, P <0.05). CONCLUSIONS: The serum level of SYK and VEGF-C are closely related to the lymph nodes metastasis of lung adenocarcinoma. Combination detection of SYK and VEGF-C might be helpful for the predict of lymph nodes metastasis of lung adenocarcinoma.