Literature DB >> 2079716

Cholinergic receptors in human brain: effects of aging and Alzheimer disease.

E Giacobini1.   

Abstract

A general review of cholinergic receptors in human brain is presented. The paper focuses upon changes in normal aging brain and in Alzheimer disease. Studies from five different approaches are reported: 1) molecular biology; 2) receptor binding studies; 3) studies with specific neurotoxins; 4) immunocytochemistry; and 5) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological Alzheimer brain with regard to cholinergic receptor localization, distribution, and function.

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Year:  1990        PMID： 2079716     DOI： 10.1002/jnr.490270416

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  11 in total

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Authors:  V C Hinz; S Grewig; B H Schmidt
Journal:  Neurochem Res       Date:  1996-03       Impact factor: 3.996

2.  Acute nicotinic blockade produces cognitive impairment in normal humans.

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Review 3.  The acetylcholine receptor ligand-gated channel as a molecular target of disease and therapeutic agents.

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4.  Contingent vulnerability of entorhinal parvalbumin-containing neurons in Alzheimer's disease.

Authors:  A Solodkin; S D Veldhuizen; G W Van Hoesen
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Review 5.  Increased regional cerebral glucose metabolism and semantic memory performance in Alzheimer's disease: a pilot double blind transdermal nicotine positron emission tomography study.

Authors:  R W Parks; R E Becker; R F Rippey; D G Gilbert; J R Matthews; E Kabatay; C S Young; C Vohs; V Danz; P Keim; G T Collins; S S Zigler; P G Urycki
Journal:  Neuropsychol Rev       Date:  1996-06       Impact factor: 7.444

Review 6.  Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders.

Authors:  Nicolaas I Bohnen; Kirk A Frey
Journal:  Mol Imaging Biol       Date:  2007 Jul-Aug       Impact factor: 3.488

7.  Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease.

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Review 8.  Inhibition of Inflammation Mediated Through the Tumor Necrosis Factor α Biochemical Pathway Can Lead to Favorable Outcomes in Alzheimer Disease.

Authors:  Daniah Shamim; Michael Laskowski
Journal:  J Cent Nerv Syst Dis       Date:  2017-07-28

Review 9.  Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's Disease.

Authors:  Touqeer Ahmed; Saadia Zahid; Aamra Mahboob; Syeda Mehpara Farhat
Journal:  Curr Neuropharmacol       Date:  2017       Impact factor: 7.363

10.  Neuroprotective effect of berberine chloride on cognitive impairment and hippocampal damage in experimental model of vascular dementia.

Authors:  Mahila Lotfi Aski; Mohammad Ebrahim Rezvani; Mehdi Khaksari; Zeynab Hafizi; Zeynab Pirmoradi; Somayeh Niknazar; Fatemeh Zare Mehrjerdi
Journal:  Iran J Basic Med Sci       Date:  2018-01       Impact factor: 2.699
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