OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS:Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
Authors: Yun Ji Jung; Hee Young Cho; Sihyun Cho; Young Han Kim; Jin Dong Jeon; Young Jin Kim; Sanghoo Lee; Jimyeong Park; Ha Yan Kim; Yong Won Park; Ja Young Kwon Journal: Yonsei Med J Date: 2017-03 Impact factor: 2.759