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Literature DB >> 2077427

Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.

M Watanabe¹, M Kinuya, G Mamiya, T Tatsunuma, M Nagayoshi, T Matsutani, Y Tsukada.

Abstract

Methylazoxymethanol (MAM)-induced cerebral hypoplasia resulted in a significant increase in densities of both serotonin uptake sites in frontal cortex and dopamine uptake sites in striatum, suggesting serotonergic and dopaminergic axons terminals were compressed in the smaller brain volumes. The density of S2 serotonin receptors in MAM-lesioned frontal cortex was decreased probably due to down-regulation, while densities of D1 and D2 dopamine receptors in striatum were identical between MAM-lesioned rats and control rats.

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Year: 1990 PMID： 2077427 DOI： 10.1007/BF00965748

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

28 in total

1. Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate.

Authors: M V Johnston; J T Coyle
Journal: J Neurochem Date: 1980-06 Impact factor: 5.372

2. Prenatal methylazoxymethanol treatment potentiates d-amphetamine- and methylphenidate-induced motor activity in male and female rats.

Authors: T Archer; A Fredriksson; E Sundström; J Luthman; T Lewander; U Söderberg; G Jonsson
Journal: Pharmacol Toxicol Date: 1988-10

3. Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

Authors: S J Peroutka; S H Snyder
Journal: Science Date: 1980-10-03 Impact factor: 47.728

4. Elevated monoamine levels in the cerebral hemispheres of microencephalic rats treated prenatally with methylazoxymethanol or cytosine arabinoside.

Authors: T Matsutani; M Nagayoshi; M Tamaru; Y Tsukada
Journal: J Neurochem Date: 1980-04 Impact factor: 5.372

5. Agonist interactions with beta-adrenergic receptors following chronic administration of desipramine or the atypical antidepressants, iprindole and mianserin.

Authors: A A Hancock; C L Marsh
Journal: J Recept Res Date: 1985

6. Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats.

Authors: W Balduini; M P Abbracchio; G Lombardelli; F Cattabeni
Journal: Brain Res Date: 1984-07 Impact factor: 3.252

7. [3H]GBR 12935 binding to dopamine uptake sites: subcellular localization and reduction in Parkinson's disease and progressive supranuclear palsy.

Authors: J M Maloteaux; M A Vanisberg; C Laterre; F Javoy-Agid; Y Agid; P M Laduron
Journal: Eur J Pharmacol Date: 1988-11-08 Impact factor: 4.432

Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.

1. Ontogeny of neurochemical markers for noradrenergic, GABAergic, and cholinergic neurons in neocortex lesioned with methylazoxymethanol acetate.

2. Prenatal methylazoxymethanol treatment potentiates d-amphetamine- and methylphenidate-induced motor activity in male and female rats.

3. Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.

4. Elevated monoamine levels in the cerebral hemispheres of microencephalic rats treated prenatally with methylazoxymethanol or cytosine arabinoside.

5. Agonist interactions with beta-adrenergic receptors following chronic administration of desipramine or the atypical antidepressants, iprindole and mianserin.

6. Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats.

7. [3H]GBR 12935 binding to dopamine uptake sites: subcellular localization and reduction in Parkinson's disease and progressive supranuclear palsy.

8. Amphetamine enhances latent dopaminergic neurotransmission in the rat striatum. Effects on 3H-acetylcholine release.

9. Guanyl nucleotide and divalent cation regulation of cortical S2 serotonin receptors.

10. Dopamine D2 receptor density remains constant in treated Parkinson's disease.

1. The distribution of serotonergic nerves in microencephalic rats treated prenatally with methylazoxymethanol.