Literature DB >> 2076726

Effect of nifedipine monotherapy on platelet aggregation in patients with untreated essential hypertension.

Z Ośmiałowska1, M Nartowicz-Słoniewska, J M Słomiński, B Krupa-Wojciechowska.   

Abstract

The effect of 6 weeks of nifedipine 30-60 mg/d on platelet aggregation and lipid parameters has been studied. A diminution in ADP-, adrenaline- and collagen-induced aggregation was observed. In the case of adrenaline- and collagen-stimulated aggregation the decrease was statistically significant. It was found that platelets which aggregated markedly during the placebo treatment were most strongly inhibited by nifedipine. The changes in lipid parameters were not significantly correlated with changes in aggregation.

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Year:  1990        PMID： 2076726     DOI： 10.1007/BF00315419

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  5 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Effects of calcium channel blockers on in vitro platelet function in whole blood using single platelet counting.

Authors:  T J Walley; K L Woods; D B Barnett
Journal:  Thromb Haemost       Date:  1989-02-28       Impact factor: 5.249

3.  The simultaneous effect of albumin bound fatty acids on platelets and endothelial cells.

Authors:  A Nordøy; B Svensson
Journal:  Thromb Res       Date:  1979       Impact factor: 3.944

4.  The effects of nifedipine, a calcium antagonist, on platelet function.

Authors:  J Dale; K H Landmark; E Myhre
Journal:  Am Heart J       Date:  1983-01       Impact factor: 4.749

Review 5.  Platelet aggregation in hypertension and the effects of antihypertensive treatment.

Authors:  M Nyrop; A J Zweifler
Journal:  J Hypertens       Date:  1988-04       Impact factor: 4.844
  5 in total
  2 in total

Review 1.  A comparative review of the adverse effects of calcium antagonists.

Authors:  H T Dougall; J McLay
Journal:  Drug Saf       Date:  1996-08       Impact factor: 5.606

2.  Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity.

Authors:  Ching-Yu Shih; I-Hsin Lin; James-Cheng Ding; Fu-Chi Chen; Tz-Chong Chou
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739
  2 in total

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