Literature DB >> 2075752

Identification of cis-3'-hydroxycotinine as a urinary nicotine metabolite.

P Voncken1, K Rustemeier, G Schepers.   

Abstract

1. cis-3'-Hydroxycotinine was detected as an S(-)-nicotine metabolite in the urine of smokers as well as in the urine of rats and hamsters dosed with nicotine. 2. The excreted amount of cis-3'-hydroxycotinine is lower than that of the trans-isomer.

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Year:  1990        PMID： 2075752     DOI： 10.3109/00498259009046633

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  4 in total

1.  Trans-3'-hydroxycotinine: disposition kinetics, effects and plasma levels during cigarette smoking.

Authors:  N L Benowitz; P Jacob
Journal:  Br J Clin Pharmacol       Date:  2001-01       Impact factor: 4.335

Review 2.  Aspects of the oxidative metabolism of nicotine.

Authors:  G B Neurath
Journal:  Clin Investig       Date:  1994-02

Review 3.  Nicotine chemistry, metabolism, kinetics and biomarkers.

Authors:  Neal L Benowitz; Janne Hukkanen; Peyton Jacob
Journal:  Handb Exp Pharmacol       Date:  2009

4.  Metabolism of S-nicotine in noninduced and aroclor-induced rats.

Authors:  G Schepers; K Rustemeier; R A Walk; U Hackenberg
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1993 Apr-Jun       Impact factor: 2.441
  4 in total

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