Literature DB >> 20740639

Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics.

Kristine L Witt1, Patricia G Moorman, Olga Kovalchuk, Nina Holland, Gladys Block, Paul R Andreassen.   

Abstract

This manuscript presents an overview of a symposium held at the 2009 annual meeting of the Environmental Mutagen Society (EMS) in St. Louis, MO. The symposium was sponsored by the Women in the Environmental Mutagen Society (WEMS) special interest group, and it covered current molecular genetics technologies and their impact on diagnosis and treatment of diseases that primarily or differentially affect women. Four speakers presented groundbreaking new information from such areas as cancer genetics, gene-environment interactions, epigenetics, DNA repair, and molecular epidemiology. Although cancer was a primary focus of the symposium, other health issues such as obesity and cardiovascular disease were addressed. The rapid evolution in genomic technologies discussed in this symposium should provide new tools to explore some of the critical questions raised by the research projects described in this article. This symposium demonstrates that EMS provides a forum for the presentation, discussion, and extension of the data generated by the investigators featured in this article and other researchers engaged in the study of the molecular mechanisms and gene-environment interactions that impact women's health.

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Year:  2010        PMID: 20740639      PMCID: PMC4936393          DOI: 10.1002/em.20607

Source DB:  PubMed          Journal:  Environ Mol Mutagen        ISSN: 0893-6692            Impact factor:   3.216


  36 in total

1.  Obesity and oxidative stress: a direct link to CVD?

Authors:  Jane V Higdon; Balz Frei
Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-03-01       Impact factor: 8.311

2.  Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

Authors:  Bing Xia; Josephine C Dorsman; Najim Ameziane; Yne de Vries; Martin A Rooimans; Qing Sheng; Gerard Pals; Abdellatif Errami; Eliane Gluckman; Julian Llera; Weidong Wang; David M Livingston; Hans Joenje; Johan P de Winter
Journal:  Nat Genet       Date:  2006-12-31       Impact factor: 38.330

3.  Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study.

Authors:  Myron Gross; Michael Steffes; David R Jacobs; Xinhua Yu; Linda Lewis; Cora E Lewis; Catherine M Loria
Journal:  Clin Chem       Date:  2004-10-28       Impact factor: 8.327

4.  The effect of vitamins C and E on biomarkers of oxidative stress depends on baseline level.

Authors:  Gladys Block; Christopher D Jensen; Jason D Morrow; Nina Holland; Edward P Norkus; Ginger L Milne; Mark Hudes; Tapashi B Dalvi; Patricia B Crawford; Ellen B Fung; Laurie Schumacher; Paul Harmatz
Journal:  Free Radic Biol Med       Date:  2008-04-16       Impact factor: 7.376

5.  A recurrent mutation in PALB2 in Finnish cancer families.

Authors:  Hannele Erkko; Bing Xia; Jenni Nikkilä; Johanna Schleutker; Kirsi Syrjäkoski; Arto Mannermaa; Anne Kallioniemi; Katri Pylkäs; Sanna-Maria Karppinen; Katrin Rapakko; Alexander Miron; Qing Sheng; Guilan Li; Henna Mattila; Daphne W Bell; Daniel A Haber; Mervi Grip; Mervi Reiman; Arja Jukkola-Vuorinen; Aki Mustonen; Juha Kere; Lauri A Aaltonen; Veli-Matti Kosma; Vesa Kataja; Ylermi Soini; Ronny I Drapkin; David M Livingston; Robert Winqvist
Journal:  Nature       Date:  2007-02-07       Impact factor: 49.962

Review 6.  Role of genetic polymorphisms and ovarian cancer susceptibility.

Authors:  Peter A Fasching; Simon Gayther; Leigh Pearce; Joellen M Schildkraut; Ellen Goode; Falk Thiel; Georgia Chenevix-Trench; Jenny Chang-Claude; Shan Wang-Gohrke; Susan Ramus; Paul Pharoah; Andrew Berchuck
Journal:  Mol Oncol       Date:  2009-02-04       Impact factor: 6.603

7.  Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression.

Authors:  Olga Kovalchuk; Volodymyr P Tryndyak; Beverly Montgomery; Alex Boyko; Kristy Kutanzi; Franz Zemp; Alan R Warbritton; John R Latendresse; Igor Kovalchuk; Frederick A Beland; Igor P Pogribny
Journal:  Cell Cycle       Date:  2007-06-06       Impact factor: 4.534

8.  Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes.

Authors:  Karen Huen; Kim Harley; Asa Bradman; Brenda Eskenazi; Nina Holland
Journal:  Toxicol Appl Pharmacol       Date:  2010-01-04       Impact factor: 4.219

Review 9.  C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.

Authors:  David I Buckley; Rongwei Fu; Michele Freeman; Kevin Rogers; Mark Helfand
Journal:  Ann Intern Med       Date:  2009-10-06       Impact factor: 25.391

10.  PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

Authors:  Nazneen Rahman; Sheila Seal; Deborah Thompson; Patrick Kelly; Anthony Renwick; Anna Elliott; Sarah Reid; Katarina Spanova; Rita Barfoot; Tasnim Chagtai; Hiran Jayatilake; Lesley McGuffog; Sandra Hanks; D Gareth Evans; Diana Eccles; Douglas F Easton; Michael R Stratton
Journal:  Nat Genet       Date:  2006-12-31       Impact factor: 38.330

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