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Literature DB >> 20739572

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.

Juan C Piña-Crespo¹, Maria Talantova, Ileana Micu, Bradley States, H-S Vincent Chen, Shichun Tu, Nobuki Nakanishi, Gary Tong, Dongxian Zhang, Stephen F Heinemann, Gerald W Zamponi, Peter K Stys, Stuart A Lipton.

Abstract

NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.

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Year: 2010 PMID： 20739572 PMCID： PMC2941801 DOI： 10.1523/JNEUROSCI.1593-10.2010

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

20 in total

Review 1. NMDA receptor subunits: function and pharmacology.

Authors: Pierre Paoletti; Jacques Neyton
Journal: Curr Opin Pharmacol Date: 2006-11-07 Impact factor: 5.547

2. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.

Authors: I Micu; Q Jiang; E Coderre; A Ridsdale; L Zhang; J Woulfe; X Yin; B D Trapp; J E McRory; R Rehak; G W Zamponi; W Wang; P K Stys
Journal: Nature Date: 2005-12-21 Impact factor: 49.962

3. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.

Authors: Michael G Salter; Robert Fern
Journal: Nature Date: 2005-12-22 Impact factor: 49.962

4. Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy.

Authors: Ileana Micu; Andrew Ridsdale; Lingqing Zhang; John Woulfe; Jeff McClintock; Christine A Brantner; S Brian Andrews; Peter K Stys
Journal: Nat Med Date: 2007-07-01 Impact factor: 53.440

5. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter.

Authors: S Li; P K Stys
Journal: J Neurosci Date: 2000-02-01 Impact factor: 6.167

6. Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.

Authors: Christian Madry; Ivana Mesic; Ingo Bartholomäus; Annette Nicke; Heinrich Betz; Bodo Laube
Journal: Biochem Biophys Res Commun Date: 2006-12-28 Impact factor: 3.575

7. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.

Authors: Marc Awobuluyi; Jin Yang; Yuzhen Ye; Jon E Chatterton; Adam Godzik; Stuart A Lipton; Dongxian Zhang
Journal: Mol Pharmacol Date: 2006-10-17 Impact factor: 4.436

8. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.

Authors: Simon M Manning; Delia M Talos; Chengwen Zhou; Debra B Selip; Hyun-Kyung Park; Chang-Joo Park; Joseph J Volpe; Frances E Jensen
Journal: J Neurosci Date: 2008-06-25 Impact factor: 6.167

9. Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.

Authors: Saraid S Billiards; Robin L Haynes; Rebecca D Folkerth; Natalia S Borenstein; Felicia L Trachtenberg; David H Rowitch; Keith L Ligon; Joseph J Volpe; Hannah C Kinney
Journal: Brain Pathol Date: 2008-01-03 Impact factor: 6.508

10. Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.

Authors: C Thetford Smothers; John J Woodward
Journal: J Pharmacol Exp Ther Date: 2007-05-14 Impact factor: 4.030

36 in total

Review 1. Synaptic neurotransmitter-gated receptors.

Authors: Trevor G Smart; Pierre Paoletti
Journal: Cold Spring Harb Perspect Biol Date: 2012-03-01 Impact factor: 10.005

Review 2. Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.

Authors: Peter K Stys; Haitao You; Gerald W Zamponi
Journal: J Physiol Date: 2012-02-06 Impact factor: 5.182

3. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.

Authors: Trine Kvist; Thomas Bielefeldt Steffensen; Jeremy R Greenwood; Fatemeh Mehrzad Tabrizi; Kasper B Hansen; Michael Gajhede; Darryl S Pickering; Stephen F Traynelis; Jette Sandholm Kastrup; Hans Bräuner-Osborne
Journal: J Biol Chem Date: 2013-09-26 Impact factor: 5.157

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits.

Review 1. NMDA receptor subunits: function and pharmacology.

2. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.

3. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.

4. Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy.

5. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter.

6. Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.

7. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors.

8. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.

9. Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia.

10. Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.

Review 1. Synaptic neurotransmitter-gated receptors.

Review 2. Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders.

3. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.

4. Arrangement of subunits in functional NMDA receptors.

5. Effects of laser polarization on responses of the fluorescent Ca²⁺ indicator X-Rhod-1 in neurons and myelin.

Review 6. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.

Review 7. The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia.

Review 8. Emerging roles of GluN3-containing NMDA receptors in the CNS.

Review 9. Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system.

Review 10. Oligodendrocyte N-methyl-D-aspartate receptor signaling: insights into its functions.