Literature DB >> 20739336

Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis.

Halina Bartosik-Psujek1, Jacek Tabarkiewicz, Krystyna Pocinska, Zbigniew Stelmasiak, Jacek Rolinski.   

Abstract

In order to evaluate the effects of vitamin D3 on monocyte-derived dendritic cells (DCs) of relapsing-remitting multiple sclerosis patients, DCs differentiation and maturation were evaluated in vitro based on surface phenotypic changes. The expression of CD14, CD83, CD1a, CD80, CD86, CD206 and C209 was analysed by fluorescence-activated cell sorting. The results reveal that vitamin D3 inhibits both the differentiation and maturation of DCs. Moreover, inhibits the secretion of IL 23/12p40 and increases the secretion of CCL2. The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs.

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Year:  2010        PMID： 20739336     DOI： 10.1177/1352458510379611

Source DB:  PubMed          Journal:  Mult Scler        ISSN： 1352-4585            Impact factor:   6.312


  16 in total

Review 1.  Vitamin D in rheumatoid arthritis-towards clinical application.

Authors:  Louisa E Jeffery; Karim Raza; Martin Hewison
Journal:  Nat Rev Rheumatol       Date:  2015-10-13       Impact factor: 20.543

2.  Relationship between vitamin D and IL-23, IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians.

Authors:  Noha M El Husseiny; Hala M Fahmy; Waleed A Mohamed; Hisham H Amin
Journal:  World J Hepatol       Date:  2012-08-27

3.  Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation.

Authors:  Charles Pierrot-Deseilligny; Sophie Rivaud-Péchoux; Pierre Clerson; Raphaël de Paz; Jean-Claude Souberbielle
Journal:  Ther Adv Neurol Disord       Date:  2012-07       Impact factor: 6.570

Review 4.  Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications.

Authors:  Manon Galoppin; Saniya Kari; Sasha Soldati; Arindam Pal; Manon Rival; Britta Engelhardt; Anne Astier; Eric Thouvenot
Journal:  Brain Commun       Date:  2022-06-30

5.  Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis.

Authors:  Charles Pierrot-Deseilligny; Jean-Claude Souberbielle
Journal:  Ther Adv Neurol Disord       Date:  2013-03       Impact factor: 6.570

6.  Vitamin D deficiency: correlation to interleukin-17, interleukin-23 and PIIINP in hepatitis C virus genotype 4.

Authors:  Mona F Schaalan; Waleed A Mohamed; Hesham H Amin
Journal:  World J Gastroenterol       Date:  2012-07-28       Impact factor: 5.742

Review 7.  Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.

Authors:  Angelo Aquino; Grazia Graziani; Ornella Franzese; Salvatore P Prete; Enzo Bonmassar; Laura Bonmassar; Stefania D'Atri
Journal:  Clin Dev Immunol       Date:  2011-03-22

8.  1(OH) vitamin D3 supplementation improves the sensitivity of the immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients-case controlled trial.

Authors:  Yasuteru Kondo; Takanobu Kato; Osamu Kimura; Tomoaki Iwata; Masashi Ninomiya; Eiji Kakazu; Masahito Miura; Takehiro Akahane; Yutaka Miyazaki; Tomoo Kobayashi; Motoyasu Ishii; Norihiro Kisara; Kumiko Sasaki; Haruo Nakayama; Takehiko Igarashi; Noriyuki Obara; Yoshiyuki Ueno; Tatsuki Morosawa; Tooru Shimosegawa
Journal:  PLoS One       Date:  2013-05-23       Impact factor: 3.240

9.  Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.

Authors:  Arash Hossein-nezhad; Avrum Spira; Michael F Holick
Journal:  PLoS One       Date:  2013-03-20       Impact factor: 3.240

Review 10.  Vitamin D for the management of multiple sclerosis.

Authors:  Vanitha A Jagannath; Graziella Filippini; Carlo Di Pietrantonj; G V Asokan; Edward W Robak; Liz Whamond; Sarah A Robinson
Journal:  Cochrane Database Syst Rev       Date:  2018-09-24
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