BACKGROUND: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). PATIENTS/ METHODS: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross-sectional study including 6516 subjects aged 25-85years who participated in a population-based health survey. RESULTS: CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high-density lipoprotein (HDL) cholesterol, C-reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P<0.0001). There was a significant interaction between age and OPG (P=0.026). The risk of being in the uppermost quartile of CIMT was reduced (OR 0.52, 95% CI 0.30-0.88) with each standard deviation (SD) higher level of OPG in subjects <45years (n=444), whereas subjects ≥55years of age (n=4884) had an increased risk of being in the uppermost quartile of CIMT (OR 1.19, 95% CI 1.10-1.29) after adjustment for traditional CVD risk factors. CONCLUSIONS: Age has a differential impact on the association between OPG and CIMT in a general population. The present findings may suggest that increased serum OPG does not promote early atherosclerosis in younger subjects.
BACKGROUND: Previous studies have reported conflicting results on the relation between serum osteoprotegerin (OPG) concentration and carotid intima media thickness (CIMT). PATIENTS/ METHODS: The present study was conducted to investigate the relations between OPG, risk factors for cardiovascular diseases (CVD) and carotid intima media thickness (CIMT) in a large cross-sectional study including 6516 subjects aged 25-85years who participated in a population-based health survey. RESULTS:CIMT increased significantly across tertiles of OPG after adjustment for traditional cardiovascular risk factors such as age, gender, smoking, total cholesterol, high-density lipoprotein (HDL) cholesterol, C-reactive protein (CRP), body mass index (BMI), systolic blood pressure, CVD and diabetes mellitus (P<0.0001). There was a significant interaction between age and OPG (P=0.026). The risk of being in the uppermost quartile of CIMT was reduced (OR 0.52, 95% CI 0.30-0.88) with each standard deviation (SD) higher level of OPG in subjects <45years (n=444), whereas subjects ≥55years of age (n=4884) had an increased risk of being in the uppermost quartile of CIMT (OR 1.19, 95% CI 1.10-1.29) after adjustment for traditional CVD risk factors. CONCLUSIONS: Age has a differential impact on the association between OPG and CIMT in a general population. The present findings may suggest that increased serum OPG does not promote early atherosclerosis in younger subjects.
Authors: M Puato; R Ramonda; A Doria; M Rattazzi; E Faggin; G Balbi; M Zanon; M Zanardo; C Tirrito; M Lorenzin; V Modesti; M Plebani; M Zaninotto; L Punzi; P Pauletto Journal: J Hum Hypertens Date: 2013-07-11 Impact factor: 3.012
Authors: Weena J Y Chen; Luuk J Rijzewijk; Rutger W van der Meer; Martijn W Heymans; Eelco van Duinkerken; Mark Lubberink; Adriaan A Lammertsma; Hildo J Lamb; Albert de Roos; Johannes A Romijn; Jan W A Smit; Jeroen J Bax; Mette Bjerre; Jan Frystyk; Allan Flyvbjerg; Michaela Diamant Journal: Cardiovasc Diabetol Date: 2011-07-19 Impact factor: 9.951
Authors: Augusto César Ferreira de Moraes; Maria Beatriz Lacerda; Luis A Moreno; Bernardo L Horta; Heráclito Barbosa Carvalho Journal: Medicine (Baltimore) Date: 2014-12 Impact factor: 1.889