BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear. METHODS: Univariate and multivariate survival analyses were performed for patients with (n = 1829) and without (n = 183) substance use. RESULTS: HNSCC-specific survival (death due to primary-HNSCC or recurrent HNSCC) and HNSCC/second primary tumor-specific survival (death due to primary-HNSCC or recurrent HNSCC or second primary tumor) were not significantly different for patients who smoked and drank alcohol (hazard ratio [HR], 1.26; 95% confidence interval [CI], 0.86-1.85) and those who did not (HR, 1.34; 95% CI, 0.96-1.88). Overall survival was significantly affected; HR for patients who smoked and drank alcohol was 1.50 (95% CI, 1.16-1.93). CONCLUSION: Although tobacco and alcohol use are the main risk factors for development of HNSCC, disease outcome was comparable in patients who did or did not use these substances. Tobacco and alcohol use affected overall survival, which emphasizes the importance of substance use cessation.
BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear. METHODS: Univariate and multivariate survival analyses were performed for patients with (n = 1829) and without (n = 183) substance use. RESULTS: HNSCC-specific survival (death due to primary-HNSCC or recurrent HNSCC) and HNSCC/second primary tumor-specific survival (death due to primary-HNSCC or recurrent HNSCC or second primary tumor) were not significantly different for patients who smoked and drank alcohol (hazard ratio [HR], 1.26; 95% confidence interval [CI], 0.86-1.85) and those who did not (HR, 1.34; 95% CI, 0.96-1.88). Overall survival was significantly affected; HR for patients who smoked and drank alcohol was 1.50 (95% CI, 1.16-1.93). CONCLUSION: Although tobacco and alcohol use are the main risk factors for development of HNSCC, disease outcome was comparable in patients who did or did not use these substances. Tobacco and alcohol use affected overall survival, which emphasizes the importance of substance use cessation.
Authors: Owen M Wilkins; Alexander J Titus; Lucas A Salas; Jiang Gui; Melissa Eliot; Rondi A Butler; Erich M Sturgis; Guojun Li; Karl T Kelsey; Brock C Christensen Journal: Cancer Epidemiol Biomarkers Prev Date: 2018-06-07 Impact factor: 4.254
Authors: Cielito C Reyes-Gibby; Karen O Anderson; Kelly W Merriman; Knox H Todd; Sanjay S Shete; Ehab Y Hanna Journal: J Pain Date: 2014-07-17 Impact factor: 5.820
Authors: Alexis J Platek; Vijayvel Jayaprakash; Mihai Merzianu; Mary E Platek; David M Cohan; Wesley L Hicks; Sathiya P Marimuthu; Timothy B Winslow; Vishal Gupta; Hassan Arshad; Moni A Kuriakose; Shiva Dibaj; James R Marshall; Mary E Reid; Graham W Warren; Anurag K Singh Journal: Laryngoscope Date: 2016-06-27 Impact factor: 3.325
Authors: Seung Hee Choi; Jeffrey E Terrell; Carol R Bradford; Tamer Ghanem; Matthew E Spector; Gregory T Wolf; Isaac M Lipkus; Sonia A Duffy Journal: Nicotine Tob Res Date: 2016-08-18 Impact factor: 4.244
Authors: F Farshadpour; S Konings; E J M Speel; G J Hordijk; R Koole; M van Blokland; P J Slootweg; J A Kummer Journal: Patholog Res Int Date: 2011-07-12
Authors: J C de Bruin-Visser; A H Ackerstaff; H Rehorst; V P Retèl; F J M Hilgers Journal: Eur Arch Otorhinolaryngol Date: 2011-06-23 Impact factor: 2.503
Authors: Jude-Kennedy C Emejulu; Igwebuike V Onyiaorah; Cornelius O Ukah; Titus Og Chukwuanukwu; Nneka Jf Osuigwe; Effiong E Akang; Adefolarin O Malomo Journal: Int Med Case Rep J Date: 2011-11-07